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N1638

Sigma-Aldrich

Nystatin Suspension

suspension, 10,000 unit/mL in DPBS, BioReagent, suitable for cell culture

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Synonym(s):
Fungicidin, Mycostatin
CAS Number:
PubChem Substance ID:
NACRES:
NA.76

product line

BioReagent

Quality Level

form

suspension

concentration

10,000 unit/mL in DPBS

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

yellow

antibiotic activity spectrum

fungi
yeast

mode of action

cell membrane | interferes

shipped in

dry ice

storage temp.

−20°C

SMILES string

C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@]2(O)C[C@H](O)[C@H]([C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\CC\C=C\C=C\[C@H](C)[C@@H](O)[C@@H]1C)O2)C(O)=O

InChI

1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key

VQOXZBDYSJBXMA-QEKUPDCNSA-N

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1 of 4

This Item
N4014N6261N3503
vibrant-m

N1638

Nystatin Suspension

vibrant-m

N4014

Nystatin

vibrant-m

N6261

Nystatin

vibrant-m

N3503

Nystatin

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

antibiotic activity spectrum

fungi, yeast

antibiotic activity spectrum

fungi, yeast

antibiotic activity spectrum

fungi, yeast

antibiotic activity spectrum

fungi, yeast

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

product line

BioReagent

product line

BioXtra

product line

BioReagent

product line

-

form

suspension

form

powder

form

powder

form

powder

General description

Chemical structure: polyene

Application

Nystatin suspension has been used:
  • to inhibit caveolin-mediated endocytosis
  • as a component of Eagle′s minimum essential medium (EMEM)
  • to enumerate lactic acid bacteria (LAB)
  • in preventing cell culture contamination and inducing interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in toll-like receptor 2 (TLR2)-expressing THP1 cells.
This product is recommended for use in cell culture applications at 24 mL/L.

Biochem/physiol Actions

Nystatin is a polyene, broad-spectrum antibiotic, which modifies the microstructure of lipid rafts. It can sequester cholesterol present on the cell membrane of eukaryotes. Nystatin regulates immune responses through cytokine signaling, lymphocyte activation and pathogen recognition.

Caution

This product is stable at 37°C for three days.

Preparation Note

It is 0.1μ filtered and cell culture tested.

Other Notes

Nystatin suspension available in 20 mL and 100 mL pack size.
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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