The Gene Encoding Nicastrin, a Major gamma-Secretase Component, Modifies Risk for Familial Early-Onset Alzheimer Disease in a Dutch Population-Based Sample
Dermaut B, et al.
American Journal of Human Genetics, 70, 1568-1574 (2002)
Aph-1 Associates Directly with Full-length and C-terminal Fragments of gamma-Secretase Substrates
Chen AC, et al.
The Journal of Biological Chemistry, 285(15), 11378-11391 (2010)
Kunihiko Kanatsu et al.
Nature communications, 5, 3386-3386 (2014-03-01)
A body of evidence suggests that aberrant metabolism of amyloid-β peptide (Aβ) underlies the aetiology of Alzheimer disease (AD). Recently, a single-nucleotide polymorphism in phosphatidylinositol binding clathrin assembly protein (PICALM/CALM) gene, which encodes a protein implicated in the clathrin-mediated endocytosis...
Sophia Schedin-Weiss et al.
Acta neuropathologica communications, 4, 29-29 (2016-04-03)
The transmembrane protein assembly γ-secretase is a key protease in regulated intramembrane processing (RIP) of around 100 type-1 transmembrane proteins. Importantly, it has a pathological role in Alzheimer disease (AD) as it generates the neurotoxic amyloid β-peptide from the amyloid...
Guojun Zhao et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(5), 1648-1656 (2010-02-05)
Gamma-secretase is a multiprotein, intramembrane-cleaving protease with a growing list of protein substrates, including the Notch receptors and the amyloid precursor protein. The four components of gamma-secretase complex--presenilin (PS), nicastrin (NCT), Pen2, and Aph1--are all thought to be essential for...