N2290

NP603

≥98% (HPLC)

• Synonym(s): (Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid, 5-[[6-(3,5-Dimethoxyphenyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
• Empirical Formula (Hill Notation): C₂₆H₂₆N₂O₅
• CAS Number: 949164-80-1
• Molecular Weight: 446.50
• NACRES: NA.77
• PubChem Substance ID: 329818411
• UNSPSC Code: 12352200
• MDL number: MFCD18632551

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: orange-red
• solubility: DMSO: ≥30 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1cc(OC)cc(c1)-c2ccc3c(NC(=O)\C3=C/c4[nH]c(C)c(CCC(O)=O)c4C)c2
• InChI: 1S/C26H26N2O5/c1-14-20(7-8-25(29)30)15(2)27-23(14)13-22-21-6-5-16(11-24(21)28-26(22)31)17-9-18(32-3)12-19(10-17)33-4/h5-6,9-13,27H,7-8H2,1-4H3,(H,28,31)(H,29,30)/b22-13-
• InChI key: ZIZSHSPAAJIYOD-XKZIYDEJSA-N

Description

Biochem/physiol Actions

NP603 is a cell-permeable inhibitor of PDGFRβ, FGFR1 and VEGFR2 that binds to ATP pocket.

NP603 is a cell-permeable inhibitor of PDGFRβ, FGFR1 and VEGFR2 that binds to ATP pocket. NP603 is a very weak inhibitor of EGFR (IC50 >100 μM).

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the FGFR and PDGFR pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable