N3136

Naltrexone hydrochloride

• Synonym(s): Naltrexone HCl
• Empirical Formula (Hill Notation): C₂₀H₂₃NO₄ · HCl
• CAS Number: 16676-29-2
• Molecular Weight: 377.86
• Beilstein: 3580333
• EC Number: 240-723-0
• MDL number: MFCD00069324
• PubChem Substance ID: 24278051
• NACRES: NA.77

Properties

• form: powder
• Quality Level: 100
• originator: Novartis
• storage temp.: 2-8°C
• SMILES string: Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6
• InChI: 1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
• InChI key: RHBRMCOKKKZVRY-ITLPAZOVSA-N
• Gene Information: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

Description

Application

Naltrexone hydrochloride has been used:

• as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
• to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
• in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

Packaging

25, 100, 250 mg

1 g

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves