N3279

Monoclonal Anti-Nerve Growth Factor-β antibody produced in mouse

clone 25623, purified immunoglobulin, lyophilized powder

• Synonym(s): Anti-NGF-β
• MDL number: MFCD00282385
• NACRES: NA.41

Properties

• Quality Level: 200
• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 25623, monoclonal
• form: lyophilized powder
• species reactivity: human, rat, mouse
• technique(s): capture ELISA: 2-8 μg/mL (detection antibody at 0.1-0.4 μg/ml); neutralization: 0.1-0.4 μg/mL
• impurities: endotoxin, tested
• isotype: IgG1
• UniProt accession no.: P01138
• storage temp.: −20°C
• Gene Information: human ... NGF(4803) ; mouse ... Ngf(18049)

Description

Immunogen

recombinant human NGF-β.

Biochem/physiol Actions

Nerve Growth factor (NGF) is a growth factor that is essential for the development and maintenance of the nervous system. NGF is composed of three non-covalently linked α, β and γ subunits. The β subunit is responsible for the biological functions of NGF. Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGF is important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. NGF is also implicated in inflammation and allergic reactions.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using Protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves