MilliporeSigma
All Photos(1)

N3385

Sigma-Aldrich

N-Nitroso-N-ethylurea

ISOPAC®

Synonym(s):
N-Ethyl-N-nitrosourea, ENU
Empirical Formula (Hill Notation):
C3H7N3O2
CAS Number:
Molecular Weight:
117.11
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

form

powder

storage temp.

−20°C

SMILES string

CCN(N=O)C(N)=O

InChI

1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)

InChI key

FUSGACRLAFQQRL-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

N-Nitroso-N-ethylurea has been used as a mutation-inducing agent.

Packaging

1 g in serum bottle
Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.
1 vial contains 1 g of material calculated on anhydrous basis.

Biochem/physiol Actions

DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.

Caution

Injecting any compatible solvent permits preparation of any desired strength solution without exposure.

Reconstitution

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Legal Information

Isopac is a registered trademark of Sigma-Aldrich Co. LLC

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Repr. 1B

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

Double cone dystrophy and RPE degeneration in the retina of the zebrafish gnn mutant.
Biehlmaier O, et al.
Investigative Ophthalmology & Visual Science, 44, 1287-1287 (2003)
Induction of mutations by ENU in the medaka germline.
Ishikawa Y
The fish biology journal Medaka, 10, 27-29 (1999)
Mouse mutagenesis using N-ethyl-N-nitrosourea (ENU).
Salinger AP and Justice MJ
Cold Spring Harbor Protocols, 4 (2008)
Katherine R Bull et al.
The Journal of pathology, 233(1), 18-26 (2013-12-03)
The study of mutations causing the steroid-resistant nephrotic syndrome in children has greatly advanced our understanding of the kidney filtration barrier. In particular, these genetic variants have illuminated the roles of the podocyte, glomerular basement membrane and endothelial cell in
Jinjun Dang et al.
Blood, 125(23), 3609-3617 (2015-04-10)
Alterations of genes encoding transcriptional regulators of lymphoid development are a hallmark of B-progenitor acute lymphoblastic leukemia (B-ALL) and most commonly involve PAX5, encoding the DNA-binding transcription factor paired-box 5. The majority of PAX5 alterations in ALL are heterozygous, and

Articles

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service