Neuron-specific enolase from human brain

≥95% (SDS-PAGE), buffered aqueous solution

Enolase, Neuron-specific from human brain, NSE, Thermolabile antigen A, 2-Phospho-D-glycerate hydro-lyase
Enzyme Commission number:
MDL number:

Quality Level


≥95% (SDS-PAGE)


buffered aqueous solution

specific activity

≥10 units/mg protein

shipped in

dry ice

storage temp.


Gene Information

human ... ENO2(2026)

General description

Neuron-specific enolase (NSE) is a neuronal form of the glycolytic enzyme enolase, which was first found in extracts of brain tissue.


Neuron-specific enolase from human brain has been used in a study to assess human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia. It has also been used in a study to investigate sinonasal teratocarcinosarcoma with rhabdoid features.

Biochem/physiol Actions

Neuron-specific enolase (NSE) is expressed in all neuronal cell types, and its expression marks the acquisition of synaptic function. Following acute neuronal injury, NSE levels are increased in neuronal cell bodies. Increased levels of NSE in serum and cerebrospinal fluid have been used as markers for injury and neuronal cell death. Tumors derived from many cell types, including most neuronal and neuroendocrine tumors, express NSE.
Neuron-specific enolase promotes survival of neurons and can provide neuroprotective effects by binding to neurons in a calcium-dependent manner.

Unit Definition

One unit causes the formation of 1.0 μmole of phospho(enol)pyruvate per minute at pH 6.8 at 25 °C

Physical form

Solution in 100 mM Tris-HCl, 5 mM MgSO4, 250 mM KCl, pH 5.0-5.2


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Transplantation of human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia
Li, F., et al.
Molecular Medicine, 6, 625-630 (2012)
Neuron-specific enolase is produced by neuroendocrine tumours
Tapia, F., et al.
Lancet, 317, 808-811 (1981)
Jo-Heon Kim et al.
Pathology international, 61(12), 762-767 (2011-12-01)
Sinonasal teratocarcinosarcoma (SNTCS) is a very rare tumor developed in the nasal cavity and paranasal sinuses. The rhabdoid phenotype represents an aggressive biological behavior, but the rhabdoid feature has hitherto not been reported in cases of SNTCS. A 46-year-old man...
T Hattori et al.
Neuroscience research, 21(3), 191-198 (1995-01-01)
We previously reported that the gamma gamma-isozyme of enolase, NSE), one of the glycolytic enzymes, promoted the survival of embryonic rat neocortical neurons in culture, but alpha alpha-isozyme (non-neuronal enolase) had no effect. In the present study, the neurotrophic effects...
Kenneth S Cohen et al.
Blood, 121(8), e50-e56 (2013-01-05)
Circulating blood CD34(+) cells consist of hematopoietic stem/progenitor cells, angiogenic cells, and endothelial cells. In addition to their clinical use in hematopoietic stem cell transplantation, CD34(+) cells may also promote therapeutic neovascularization. Therefore, understanding the factors that influence circulating CD34(+)...
Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism through its actions on muscle, liver, and adipose tissue.
Read More

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.