N6136

Sigma-Aldrich

Nickel(II) chloride hexahydrate

BioReagent, suitable for cell culture

Linear Formula:
NiCl2 · 6H2O
CAS Number:
Molecular Weight:
237.69
MDL number:
PubChem Substance ID:
NACRES:
NA.71

Quality Level

product line

BioReagent

form

powder

application(s)

cell culture | mammalian: suitable

SMILES string

[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].Cl[Ni]Cl

InChI

1S/2ClH.Ni.6H2O/h2*1H;;6*1H2/q;;+2;;;;;;/p-2

InChI key

LAIZPRYFQUWUBN-UHFFFAOYSA-L

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Application

Nickel(II) chloride hexahydrate has been used:
  • in the preparation of nickel platting solution for galvanostatically coating nickel inside the reduced carbon layer during the synthesis of multiwall carbon nanotube micromotors
  • in screening of metals for inflammatory effect on vascular endothelial cells
  • as an additive in artificial cerebrospinal fluid (ACSF) to analyse excitatory post synaptic currents (EPSPs) in the hippocampus slices

Packaging

100, 500 g in glass bottle

Biochem/physiol Actions

Nickel (Ni) is an essential trace element that plays an important role in the structure and function of DNA, RNA and protein. It has toxic effects on renal, pulmonary and cardiovascular system at higher concentrations. Nickel is implicated in carcinogenesis. Ni2+ ions is a clastogenic agent. Nickel ions (Ni2+) is a non-specific voltage-gated calcium channel blocker.

Signal Word

Danger

Target Organs

Lungs

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN3288 - class 6.1 - PG 3 - EHS - RQ - Toxic solid, inorganic, n.o.s., HI: all

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium
Salnikow K and Zhitkovich A
Chemical Research in Toxicology, 21(1), 28-44 (2007)
Nonrandom chromosomal alterations in nickel-transformed Chinese hamster embryo cells
Conway K and Costa M
Cancer Research, 49(21), 6032-6038 (1989)
Studies on the genotoxic effect of nickel chloride in mice and the possible protective role of soybean seeds extracts
Fahmy MA, et al.
Global Journal of Pharmacology, 8(4), 625-634 (2014)
Effects of chemostimuli on [Ca2+] i responses of rat aortic body type I cells and endogenous local neurons: comparison with carotid body cells
Piskuric NA and Nurse CA
The Journal of Physiology, 590(9), 2121-2135 (2012)
Surfactant-Free beta-Galactosidase Micromotors for ?On-The-Move? Lactose Hydrolysis
Maria-Hormigos R, et al.
Advances in Functional Materials, 28(25), 1704256-1704256 (2018)

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