N6414

NN-DNJ

≥98% (HPLC)

• Empirical Formula (Hill Notation): C₁₅H₃₁NO₄
• CAS Number: 81117-35-3
• Molecular Weight: 289.41
• MDL number: MFCD00905846
• PubChem Substance ID: 329818665
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: >10 mg/mL
• storage temp.: −20°C
• SMILES string: CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
• InChI: 1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1
• InChI key: FTSCEGKYKXESFF-LXTVHRRPSA-N

Description

Biochem/physiol Actions

NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves