N7261

Nortriptyline hydrochloride

Name: Nortriptyline hydrochloride
Brand: SIGMA
Price: 88.4 USD
Availability: InStock

≥98% (HPLC), norepinephrine and serotonin inhibitor, powder

Synonym(s):

3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine hydrochloride, Desmethylamitriptyline hydrochloride

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10 G

$88.40

Estimated to ship onMarch 25, 2026Details

About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₁N · HCl

CAS Number:

894-71-3

Molecular Weight:

299.84

NACRES:

NA.77

PubChem Substance ID:

24278107

UNSPSC Code:

41116107

EC Number:

212-973-0

MDL number:

MFCD00058024

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

Key Documents

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Product Name

Nortriptyline hydrochloride, ≥98% (HPLC), powder

InChI key

SHAYBENGXDALFF-UHFFFAOYSA-N

InChI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H

SMILES string

Cl.CNCC\C=C1\c2ccccc2CCc3ccccc13

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

ethanol: 100 mg/mL, H₂O: soluble

originator

Eli Lilly

Quality Level

200

Gene Information

human ... HTR2A(3356), HTR2B(3357), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)

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Bioactive Small Molecule Inhibitors

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Show Differences

1 of 4

This Item	BP269	N1280000	N-907
Sigma-Aldrich N7261 Nortriptyline hydrochloride	BP269 Nortriptyline hydrochloride	N1280000 Nortriptyline hydrochloride	Supelco N-907 Nortriptyline hydrochloride solution
assay ≥98% (HPLC)	assay -	assay -	assay -
form powder	form solid	form -	form liquid
Quality Level 200	Quality Level -	Quality Level -	Quality Level 300
solubility ethanol: 100 mg/mL, H₂O: soluble	solubility -	solubility -	solubility -
originator Eli Lilly	originator -	originator -	originator -
color white to off-white	color -	color -	color -

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (K_i = 3.4 nM) than the serotonin transporter (K_i = 161 nM). 5-HT₂ serotonin receptor antagonist.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Self-report and clinician-rated measures of depression severity: can one replace the other?

Rudolf Uher et al.

Depression and anxiety, 29(12), 1043-1049 (2012-08-31)

It has been suggested that clinician-rated scales and self-report questionnaires may be interchangeable in the measurement of depression severity, but it has not been tested whether clinically significant information is lost when assessment is restricted to either clinician-rated or self-report

Adsorption behaviors of neutral and ionizable compounds on hybrid stationary phases in the absence (BEH-C18) and the presence (CSH-C18) of immobile surface charges.

Fabrice Gritti et al.

Journal of chromatography. A, 1282, 58-71 (2013-02-21)

The adsorption behaviors of a neutral (caffeine) and a positively charged compound (nortriptylinium) are investigated on two RPLC/hybrid stationary phases, eluted with a low ionic strength buffer (phosphate buffer, W(S)pH 2.63, I=10mM). The first phase, bridge ethylene hybrid (BEH), is

Sudden cardiac arrest associated with use of a non-cardiac drug that reduces cardiac excitability: evidence from bench, bedside, and community.

Abdennasser Bardai et al.

European heart journal, 34(20), 1506-1516 (2013-02-22)

Non-cardiac drugs that impair cardiac repolarization (electrocardiographic QT prolongation) are associated with an increased sudden cardiac arrest (SCA) risk. Emerging evidence suggests that non-cardiac drugs that impair cardiac depolarization and excitability (electrocardiographic QRS prolongation) also increase the risk for SCA.

Non-random dropout and the relative efficacy of escitalopram and nortriptyline in treating major depressive disorder.

Robert A Power et al.

Journal of psychiatric research, 46(10), 1333-1338 (2012-07-10)

Most comparisons of the efficacy of antidepressants have relied on the assumption that missing data are randomly distributed. Dropout rates differ between drugs, suggesting this assumption may not hold true. This paper examines the effect of non-random dropout on a

SSRIs: a premature burial.

K Jensen

Clinical pharmacology and therapeutics, 93(3), 234-235 (2012-12-20)

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