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MilliporeSigma

N8161

NS309

≥98% (HPLC),  Ca2+-activated IK/SK potassium channel activator, solid

Synonym(s):

3-Oxime-6,7-dichloro-1H-indole-2,3-dione

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$178.00

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About This Item

Empirical Formula (Hill Notation):
C8H4Cl2N2O2
CAS Number:
18711-16-5
Molecular Weight:
231.04
UNSPSC Code:
12352200
PubChem Substance ID:
329818681
NACRES:
NA.77
MDL number:
MFCD06798346
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
200

Key Documents

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Product Name

NS309, ≥98% (HPLC), solid

SMILES string

O\N=C1\C(=O)Nc2c(Cl)c(Cl)ccc12

InChI key

CVOUSAVHMDXCKG-UHFFFAOYSA-N

InChI

1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: 22 mg/mL

storage temp.

2-8°C

Quality Level

200

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This Item
V4515S3442H9415
NS309 ≥98% (HPLC), solid

Sigma-Aldrich

N8161

NS309

VU0238429 solubility: ≥20 mg/mL in DMSO

Sigma-Aldrich

V4515

VU0238429

SB 216763 >98% (HPLC)

Sigma-Aldrich

S3442

SB 216763

5HPP-33 ≥98% (HPLC), solid

Sigma-Aldrich

H9415

5HPP-33

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

>98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

form

-

form

solid

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 22 mg/mL

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: soluble 20 mg/mL, H2O: insoluble

solubility

DMSO: >20 mg/mL

color

yellow

color

orange

color

orange

color

white to off-white

Biochem/physiol Actions

NS309 is a Ca2+-activated IK/SK potassium channel activator.

Disclaimer

air sensitive

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000469795
0000469794
0000469794
0000469795
0000192343

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Cara C Rada et al.
American journal of physiology. Endocrinology and metabolism, 307(10), E935-E943 (2014-09-25)
Proper placental perfusion is essential for fetal exchange of oxygen, nutrients, and waste with the maternal circulation. Impairment of uteroplacental vascular function can lead to pregnancy complications, including preeclampsia and intrauterine growth restriction (IUGR). Potassium channels have been recognized as
Kanwal Sakhi et al.
The Journal of physiology, 592(4), 587-603 (2013-11-20)
Intrinsic daily or circadian rhythms arise through the outputs of the master circadian clock in the brain's suprachiasmatic nuclei (SCN) as well as circadian oscillators in other brain sites and peripheral tissues. SCN neurones contain an intracellular molecular clock that
Erik J Behringer et al.
The Journal of physiology, 595(24), 7347-7368 (2017-10-11)
Endothelial cell function in resistance arteries integrates Ca Subsequent to a rise in intracellular Ca
Abbie C Johnson et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(8), 2857-2869 (2016-11-07)
We investigated the effect of experimental preeclampsia on hyperemia during seizure in the hippocampus and vascular function and structure of hippocampal arterioles using Sprague Dawley rats (n = 14/group) that were nonpregnant, pregnant (d20), or had experimental preeclampsia (induced by a high
Jackson T Fontaine et al.
Mechanisms of ageing and development, 192, 111389-111389 (2020-11-01)
Vascular cognitive impairment, the second most common cause of dementia, profoundly affects hippocampal-dependent functions. However, while the growing literature covers complex neuronal interactions, little is known about the sustaining hippocampal microcirculation. Here we examined vasoconstriction to physiological pressures of hippocampal
View All Related Papers

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