This product is a mixture of Oleic acid and Cyclodextrin. Each gram of powder will include a minimum of 28 mg Oleic acid. The product is sold by Oleic acid content. At the minimum Oleic acid content, the 10 mg package size would contain a total of 357 mg of powder. The Oleic acid content is lot specific. Please see the link below to review a sample or lot specific Certificate of Analysis:
https://www.sigmaaldrich.com/product/sigma/o1257#product-documentation
O1257
Oleic Acid-Water Soluble
powder, BioReagent, suitable for cell culture
Synonym(s):
Oleic Acid–Cyclodextrin Complex
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Product Name
Oleic Acid-Water Soluble, powder, BioReagent, suitable for cell culture
InChI
1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-
SMILES string
CCCCCCCC\C=C/CCCCCCCC(O)=O
InChI key
ZQPPMHVWECSIRJ-KTKRTIGZSA-N
biological source
synthetic (organic)
product line
BioReagent
form
powder
composition
Oleic acid, ~30 mg/g (balance methyl-β-cyclodextrin)
technique(s)
cell culture | mammalian: suitable
solubility
H2O: 50 mg/mL, clear to slightly hazy
storage temp.
−20°C
Quality Level
Gene Information
human ... SOAT1(6646), SOAT2(8435)
Related Categories
1 of 4
This Item | E4637 | O3008 | D2915 |
|---|---|---|---|
| biological source synthetic (organic) | biological source semisynthetic | biological source bovine | biological source synthetic (organic) |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| solubility H2O: 50 mg/mL, clear to slightly hazy | solubility - | solubility - | solubility H2O: 25 mg/mL, clear to slightly hazy |
| form powder | form powder | form liquid | form solid |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. room temp |
| composition Oleic acid, ~30 mg/g (balance methyl-β-cyclodextrin) | composition - | composition Oleic acid, 2 mol/mol albumin | composition - |
Application
Oleic Acid-Water Soluble has been used:
- to prepare the FFAs (free fatty acids) mixture for cell treatment[1]
- to investigate its effect on the solute carrier family 2 member 4 (SLC2A4)/GLUT4 expression in L6 muscle cells and as potential transcriptional regulators[2]
- in the preparation of fatting media for the induction of in vitro steatosis in primary human hepatocytes[3]
Other Notes
Methyl-β-cylodextran binding improves the solubility and delivery of Oleic acid in culture media.
related product
Product No.
Description
Pricing
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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Oleic and linoleic fatty acids downregulate Slc2a4/GLUT4 expression via NFKB and SREBP1 in skeletal muscle cells
Poletto A C, et al.
Molecular and Cellular Endocrinology, 401(12), 65-72 (2015)
Shuo Li et al.
International journal of biological sciences, 17(15), 4165-4175 (2021-11-23)
Background: Inflammation and apoptosis play a crucial role in the progression of nonalcoholic steatohepatitis (NASH). Suppressor of cytokine signaling 2 (SOCS2) is one of classic negative regulators of cytokine signaling, which has recently been described as anti-inflammatory mediators. However, the
A20 attenuates FFAs-induced lipid accumulation in nonalcoholic steatohepatitis
Ai L, et al.
International Journal of Biological Sciences, 11(12), 1436-1436 (2015)
Kangpeng Jin et al.
Theranostics, 10(12), 5290-5304 (2020-05-07)
Rationale: Inflammation plays a crucial role in the progression of nonalcoholic steatohepatitis (NASH). Protein tyrosine phosphatase receptor type O truncated isoform (PTPROt) is an integral membrane protein that has been identified in osteoclasts, macrophages, and B lymphocytes. However, its relationship
Pu Sun et al.
Journal for immunotherapy of cancer, 9(8) (2021-08-11)
The phosphatidylinositol 3-kinase (PI3K) is frequently hyperactivated in cancer and plays important roles in both malignant and immune cells. The effect of PI3Kα inhibitors on the tumor microenvironment (TME) remains largely unknown. Here, we investigated the modulation of the TME
Articles
How the unsaturated fatty acid, oleic acid and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.
Supplement cell culture systems with fatty acids for biomanufacturing heterologous proteins like monoclonal antibodies.
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Could you please clarify whether the entire 10mg of the compound is oleic acid, or does the 10mg compound actually contain 377ug (37.7mg/g * 10mg) of oleic acid, considering the specified concentration?
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