O1266

OPC 31260 hydrochloride

≥98% (HPLC)

• Synonym(s): 5-(Dimethylamino)-1-[4-(2-methylbenzamido)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride, Mozavaptan hydrochloride, N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide hydrochloride
• Empirical Formula (Hill Notation): C₂₇H₂₉N₃O₂ · HCl
• CAS Number: 138470-70-9
• Molecular Weight: 464.00
• MDL number: MFCD11111965
• UNSPSC Code: 51111800
• PubChem Substance ID: 329818895
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥15 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c4ccccc14
• InChI: 1S/C27H29N3O2.ClH/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30;/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31);1H
• InChI key: MOROBKPIULFQDC-UHFFFAOYSA-N

Description

Biochem/physiol Actions

OPC 31260 is a vasopressin V2 selective antagonist. Arginine vasopressin (AVP) plays an important part in circulatory and water homeostasis. The V2 receptor subtype is important in water retention, cardiac remodeling in congestive heart failure (CHF), and renal hemodynamic alterations, and is considered a target for polysystic kidney disease. OPC-31260 has been shown to inhibit the development of polycystic kidney disease in several animal models.

Vasopressin V2 selective antagonist.

Caution

air-sensitive, hygroscopic, store with desiccant

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable