Wrapping the vial in aluminum foil is an effective method to protect the product from light. Research indicates that light can significantly impact the activity of certain compounds, including oleic acid.
O1383
Oleic acid
suitable for cell culture, BioReagent
Synonym(s):
cis-9-Octadecenoic acid, Elainic acid
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1 G
$40.90
5 G
$134.00
25 G
$235.00
About This Item
Linear Formula:
CH3(CH2)7CH=CH(CH2)7COOH
CAS Number:
Molecular Weight:
282.46
UNSPSC Code:
12352211
NACRES:
NA.75
PubChem Substance ID:
EC Number:
204-007-1
Beilstein/REAXYS Number:
1726542
MDL number:
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Product Name
Oleic acid, suitable for cell culture, BioReagent
technique(s)
cell culture | mammalian: suitable
InChI key
ZQPPMHVWECSIRJ-KTKRTIGZSA-N
InChI
1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-
SMILES string
CCCCCCCC\C=C/CCCCCCCC(O)=O
biological source
palm oil
vapor pressure
1 mmHg ( 176 °C)
product line
BioReagent
assay
≥99% (GC)
form
viscous liquid
refractive index
n20/D 1.459 (lit.)
bp
194-195 °C/1.2 mmHg (lit.)
mp
13-14 °C (lit.)
solubility
ethanol: soluble
density
0.89 g/mL at 25 °C (lit.)
0.89 g/mL at 25 °C (lit.)
storage temp.
−20°C
Quality Level
Gene Information
human ... SOAT1(6646), SOAT2(8435)
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Related Categories
1 of 4
This Item | 27728 | 75090 | PHR1586 |
|---|---|---|---|
| assay ≥99% (GC) | assay 65.0-88.0% (GC) | assay ≥98.5% (GC) | assay - |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable |
| biological source palm oil | biological source - | biological source - | biological source - |
| form viscous liquid | form liquid | form - | form - |
| storage temp. −20°C | storage temp. - | storage temp. −20°C | storage temp. 2-30°C |
| solubility ethanol: soluble | solubility - | solubility - | solubility - |
Application
Disclaimer
Unsaturated fatty acids are subject to oxidation and peroxidation. Consider complexed fatty acid supplements.
General description
Oleic acid is a mono-unsaturated omega-9 fatty acid created by dehydrogenation of stearic acid. It is then further dehydrogenated and elongated to create members of the n-9 family of fatty acids. Oleic acid is not an essential fatty acid (EFA); however, providing it to cells in culture reduces energy demand.
Oleic acid mediates complete oxidation of fatty acid in sirtuin1- proliferator-activated receptor γ coactivator−1α (SIRT1-PGC-1α) signalling pathway. Oleic acid shows anti-inflammatory properties related to atherosclerosis and insulin resistant state.[1] Oleic acid inhibits permeability in gap junctions and promotes glucose uptake in astrocytes. Oleic acid aids in neural cell proliferation by increasing glucose uptake and by protein kinase C (PKC) activation. Oleic acid is essential for axonal growth and neuronal clustering.[4]
Packaging
Sealed ampule.
Storage Class
10 - Combustible liquids
wgk
WGK 1
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1alpha complex
Lim JH, et al.
The Journal of Biological Chemistry, 288(10), 7117-7126 (2013)
Beneficial effect of fish oil on human brain (2009)
Three-dimensional label-free imaging and quantification of lipid droplets in live hepatocytes
Kim K, et al.
Scientific Reports, 6(10), 36815-36815 (2016)
The role of proliferator-activated receptor gamma coactivator-1alpha in the fatty-acid-dependent transcriptional control of interleukin-10 in hepatic cells of rodents
Morari J, et al.
Metabolism, Clinical and Experimental, 59(2), 215-223 (2010)
Joyce Wang et al.
BMC genomics, 15, 415-415 (2014-06-03)
Mycobacterium avium subsp. paratuberculosis (MAP) is an obligate intracellular pathogen that infects many ruminant species. The acquisition of foreign genes via horizontal gene transfer has been postulated to contribute to its pathogenesis, as these genetic elements are absent from its
Articles
Lipid Induced Insulin Resistance
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Do you have any recommendations for protecting the product from light when diluting the stock solution from the ampule? Is there any research suggesting that light significantly impacts the activity of the compound?
1 answer-
Helpful?
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Could you please provide info on: 1) solvent for dissolving oleic acid (DMSO or ethanol), 2) BSA inclusion (is it recommended?) , and 4) preparation/storage conditions for the stock solution?
1 answer-
This product is soluble in CHCl3 at 50 mg/mL without BSA. No testing has been conducted on DMSO or ethanol. Some literature indicates solubility in ethanol (>25 mg/mL) and DMSO (100 mg/mL). Storage conditions for the prepared solution have not been tested. Literature suggests that aliquots can be stored at -80°C for 6 months and at -20°C for 1 month. Further research is recommended for optimal use.
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Hello. I would like to know if it is necessary to sonicate the oleic acid before stimulation? what is the best solvent? Thank you!
1 answer-
Ethanol is commonly used as a solvent for reconstitution of this product for cell culture applications. Although solubility in ethanol is not a tested specification for batch release, this product is known to dissolve in ethanol up to a concentration of 20 mg/mL. Sonication is not necessary for reconstitution in ethanol.
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What is the concentration of this oleic acid and what solvent do I need to make dilution
1 answer-
This product is a neat or pure liquid and has not been diluted. This material has a density of 0.890 g/mL and a molecular weight of 282.46 g/mol. The minimum purity is 99%, thus the molarity will vary slightly from lot to lot. The molarity can range from 3.12 M (99%) to 3.15 M (100%).
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What is the concentration of this product-O1383-25G?
1 answer-
The concentration of this product can be determined using the lot-specific purity reported in the Certificate of Analysis, as well as the density and compound molecular weight. This product has a density of 0.89 g/mL and a molecular weight of 282.46 g/mol. The minimum purity is 99%, thus the molarity will vary slightly from lot to lot. The molarity can range from 3.12 M (99%) to 3.15 M (100%).
Helpful?
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Has product O1383-25g been received in a glass container or ampule?
1 answer-
Based on the packaging information, product O1383-25g has been received in a glass ampule.
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