O2375

L-Ornithine monohydrochloride

≥99%

• Synonym(s): (S)-2,5-Diaminopentanoic acid monohydrochloride
• Empirical Formula (Hill Notation): C₅H₁₂N₂O₂ · HCl
• CAS Number: 3184-13-2
• Molecular Weight: 168.62
• Beilstein: 3625847
• EC Number: 221-678-6
• MDL number: MFCD00064562
• PubChem Substance ID: 24897960
• NACRES: NA.26

Properties

• Quality Level: 200
• assay: ≥99%
• form: powder
• impurities: ammonia and citrulline, essentially free
• color: white
• application(s): cell analysis
• SMILES string: Cl.NCCC[C@H](N)C(O)=O
• InChI: 1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1
• InChI key: GGTYBZJRPHEQDG-WCCKRBBISA-N

Description

Application

L-Ornithine monohydrochloride has been used to study the blocking effect of L-ornithine on the transport system that carries L-arginine for the overproduction of nitric oxide during lipopolysaccharide induced endotoxemia in rat model. It has also been used in decarboxylation test of amino acids.

Packaging

10 mg in glass bottle

1, 5, 25, 100 g in poly bottle

1, 5 kg

Biochem/physiol Actions

L-Ornithine is a product of arginase degradation and plays an important role in ammonia metabolism via the urea cycle. In mammals, ornithine serves as a precursor for polyamines and proline biosynthesis. Spermine synthesized from ornithine, is an abundant polyamine observed in tumors such as breast carcinomas. Administration of L-ornithine is known to improve subjective index of sleep quality. L-ornithine reduces the cortisol/DHEA-S (dehydroepiandrosterone) ratio, that is associated with stress. In mice, L-ornithine is found to affect the levels of plasma growth hormone, corticosterone and melatonin levels in mice.

Other Notes

Product of arginine degradation by arginase

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves