MilliporeSigma
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O2375

Sigma-Aldrich

L-Ornithine monohydrochloride

≥99%

Synonym(s):
(S)-2,5-Diaminopentanoic acid monohydrochloride
Empirical Formula (Hill Notation):
C5H12N2O2 · HCl
CAS Number:
Molecular Weight:
168.62
Beilstein:
3625847
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.26

Quality Level

assay

≥99%

form

powder

impurities

ammonia and citrulline, essentially free

color

white

application(s)

cell analysis

SMILES string

Cl.NCCC[C@H](N)C(O)=O

InChI

1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1

InChI key

GGTYBZJRPHEQDG-WCCKRBBISA-N

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Application

L-Ornithine monohydrochloride has been used to study the blocking effect of L-ornithine on the transport system that carries L-arginine for the overproduction of nitric oxide during lipopolysaccharide induced endotoxemia in rat model. It has also been used in decarboxylation test of amino acids.

Packaging

10 mg in glass bottle
1, 5, 25, 100 g in poly bottle
1, 5 kg

Biochem/physiol Actions

L-Ornithine is a product of arginase degradation and plays an important role in ammonia metabolism via the urea cycle. In mammals, ornithine serves as a precursor for polyamines and proline biosynthesis. Spermine synthesized from ornithine, is an abundant polyamine observed in tumors such as breast carcinomas. Administration of L-ornithine is known to improve subjective index of sleep quality. L-ornithine reduces the cortisol/DHEA-S (dehydroepiandrosterone) ratio, that is associated with stress. In mice, L-ornithine is found to affect the levels of plasma growth hormone, corticosterone and melatonin levels in mice.

Other Notes

Product of arginine degradation by arginase

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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