O3251

Oxytocin

• Synonym(s): α-Hypophamine, Oxytocic hormone
• Empirical Formula (Hill Notation): C₄₃H₆₆N₁₂O₁₂S₂
• CAS Number: 50-56-6
• Molecular Weight: 1007.19
• UNSPSC Code: 51111800
• NACRES: NA.32
• PubChem Substance ID: 24897975
• EC Number: 200-048-4
• Beilstein/REAXYS Number: 3586108
• MDL number: MFCD00076731
• Biological source: synthetic (organic)
• Form: lyophilized powder
• Assay: ≥97% (HPLC)

Properties

• InChI key: XNOPRXBHLZRZKH-DSZYJQQASA-N
• InChI: 1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1
• SMILES string: [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O
• biological source: synthetic (organic)
• sterility: non-sterile
• assay: ≥97% (HPLC)
• form: lyophilized powder
• UniProt accession no.: P01178; P30559; P70536
• shipped in: ambient
• storage temp.: 2-8°C
• Quality Level: 200
• Gene Information: human ... OXT(5020), OXTR(5021) ; rat ... Oxtr(25342)

Description

Application

Oxytocin has been used in experimental study to induce uterine contractions in rats.[1] It has been used in comet assay to determine the number of cells with DNA damage.[2]

Biochem/physiol Actions

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation.[3] OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation.[4] Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity.[5] OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings.[6] Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).[7]

Stimulates uterine contraction and lactation; increases Na⁺ excretion; stimulates myometrial GTPase and phospholipase C.

General description

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13.[3][4] It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.[3]

Physical form

Supplied as a powder with a peptide content of ≥ 75%

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable