Orexin B rat, mouse

≥97% (HPLC)

Hypocretin 2
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
MDL number:
Pricing and availability is not currently available.

Quality Level




≥97% (HPLC)




1% acetic acid: 1.00-1.04 mg/mL, clear, colorless
water: 1.00-1.04 mg/mL, clear, colorless

shipped in


storage temp.




InChI key


Gene Information

mouse ... Hcrt(15171)
rat ... Hcrt(25723)

Amino Acid Sequence


General description

Orexin A, also known as hypocretin 1 (hcrt1), is a 33 amino acid excitatory neuropeptide, localized in a small set of neurons in the perifornical area of the hypothalamus. It is synthesized from the precursor protein prepro-orexin in neurons. Orexin A binds to its G-protein-coupled receptor orexin-1 (OX1), which is also called as hcrt receptors 1 (hcrtr1).


Orexin B rat, mouse has been used to test its effect on social interaction in the stress-resilient mice.


0.1, 0.5 mg in serum bottle

Biochem/physiol Actions

Orexins (hypocretins) comprise a family of hypothalamic peptides that are involved in the initiation of sleep and in feeding behavior. Orexin A stimulates food intake through activation of the OX1 receptor. Orexin B activates OX2 receptors. Both OX1 and OX2 receptors are involved in maintaining arousal. OX2 receptors appear to be inhibitory autoreceptors on orexin-containing neurons.
Orexins plays a vital role in several physiological functions including feeding, neuroendocrine regulation and arousal. In addition to this, it is also associated with the pathophysiology of narcolepsy. Orexin A, expressed in locus coeruleus (LC) area, binds to orexin-1 (OX1) receptor and regulates rapid eye movement (REM) sleep by acting on the firing rate of noradrenergic neurons. Orexin A release is regulated by suprachiasmatic nucleus (SCN).

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Orexin administration to mice that underwent chronic stress produces bimodal effects on emotion-related behaviors
Chung HS, et al.
Regulatory Peptides, 194, 16-22 (2014)
Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons.
Bourgin P
The Journal of Neuroscience (2000)
Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of hypocretin-1 release.
Zhang S
Sleep (2004)
Hoyoung An et al.
Journal of Alzheimer's disease : JAD, 58(1), 253-261 (2017-04-08)
Intracranial accumulation of amyloid-β (Aβ) is a characteristic finding of Alzheimer's disease (AD). It is thought to be the result of Aβ overproduction by neurons and impaired clearance by several systems, including degradation by microglia. Sleep disturbance is now considered...

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