P0048

Sigma-Aldrich

Pemoline

≥98% (HPLC)

Synonym(s):
Phenylisohydantoin, 2-Amino-5-phenyl4(5H)-oxazolone
Empirical Formula (Hill Notation):
C9H8N2O2
CAS Number:
Molecular Weight:
176.17
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

solid

drug control

USDEA Schedule IV; Home Office Schedule 4.2; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

solubility

DMSO: 28 mg/mL

originator

Boehringer Ingelheim

storage temp.

2-8°C

SMILES string

NC1=NC(=O)C(O1)c2ccccc2

InChI

1S/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12)

InChI key

NRNCYVBFPDDJNE-UHFFFAOYSA-N

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Biochem/physiol Actions

Pemoline is a CNS stimulant. Pemoline is used to treat attention-deficit hyperactivity disorder (ADHD). Pemoline is a Schedule IV drug and offers some advantages over other stimulants in that it does not reduce the appetite or cause dry mouth.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Fatma A Etwel et al.
Drug safety, 31(2), 169-180 (2008-01-26)
Pemoline is a CNS stimulant that was introduced in 1975 in the US and was used to treat children with attention deficit hyperactivity disorder. Pemoline was withdrawn from the market 30 years later because of fatal hepatotoxicity associated with its...
Amber M Muehlmann et al.
Behavioural brain research, 189(1), 32-40 (2008-02-05)
Self-injurious behaviour (SIB) is exhibited by individuals with a broad variety of developmental disorders and genetic abnormalities, including autism and Lesch-Nyhan, Prader-Willi and Rett syndromes. Most research has focused on environmental factors that reinforce SIB, and less is known about...
Gideon Koren et al.
Handbook of experimental pharmacology, 205, 169-180 (2011-09-02)
It typically takes many years before an association of a drug with a rare, serious adverse reaction is established. As related to pediatric drug use, evidence is even more erratic, as most drugs are used off labels. To enhance child...
Pharmacologic treatments for fatigue associated with palliative care.
Marilyn Kirshbaum
Clinical journal of oncology nursing, 15(4), 438-439 (2011-08-04)
Darragh P Devine
Methods in molecular biology (Clifton, N.J.), 829, 155-163 (2012-01-11)
Traditional models of neuropsychiatric disorders consist of attempts to replicate the broad spectrum of behavioural and neurochemical sequelae that characterize a specific disorder. However, these disorders comprise complex constellations of symptoms, including emotional instability, perseverative thoughts, and aberrant behaviours. Close...
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