P0430

Periodic acid

suitable for electrophoresis, ≥99%

• Synonym(s): Iodic acid, Orthoperiodic acid, Paraperiodic acid
• Empirical Formula (Hill Notation): H₅IO₆
• CAS Number: 10450-60-9
• Molecular Weight: 227.94
• EC Number: 233-937-0
• MDL number: MFCD00011344
• UNSPSC Code: 41105319
• PubChem Substance ID: 24898104
• NACRES: NB.22

Properties

• grade: electrophoresis grade
• assay: ≥99%
• form: powder or crystals
• reaction suitability: reagent type: oxidant
• technique(s): electrophoresis: suitable
• mp: 122 °C (lit.)
• solubility: water: 100 mg/mL, clear, colorless
• SMILES string: OI(O)(O)(O)(O)=O
• InChI: 1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)
• InChI key: TWLXDPFBEPBAQB-UHFFFAOYSA-N

Description

Application

Periodic acid is commonly used as a component for glycoprotein stains[1]. Selective staining of glycoproteins on SDS-PAGE and membranes is carried out using a modification of the Periodic Acid-Schiff (PAS) method. Staining of sugar moieties of glycoproteins yields magenta bands with a colorless background. The Periodic Acid/Schiff Reagent stains vicinal diol groups found mainly on peripheral sugars and sialic acids and is used as a general glycoprotein stain[2]. Periodic acid is also used to cleave reversible cross-linkers (e.g. DATD, DHEBA) in PAGE gels.

Analysis Note

Tested for use in staining of glycoproteins.

Safety Information

• pictograms: GHS03,GHS08,GHS05,GHS09
• signalword: Danger
• hcodes: H271,H314,H372,H410
• pcodes: P210 - P260 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral
• target_organs: Thyroid
• Storage Class: 5.1A - Strongly oxidizing hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges