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P0500

Sigma-Aldrich

Palmitic acid

≥99%

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Synonym(s):
1-Pentadecanecarboxylic acid, C16:0, Cetylic acid, Hexadecanoic acid, NSC 5030, PamOH
Linear Formula:
CH3(CH2)14COOH
CAS Number:
Molecular Weight:
256.42
Beilstein/REAXYS Number:
607489
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

vapor pressure

10 mmHg ( 210 °C)

assay

≥99%

form

powder

bp

271.5 °C/100 mmHg (lit.)

mp

61-62.5 °C (lit.)

density

0.852 g/mL at 25 °C (lit.)

functional group

carboxylic acid

lipid type

saturated FAs

shipped in

ambient

storage temp.

room temp

SMILES string

CCCCCCCCCCCCCCCC(O)=O

InChI

1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)

InChI key

IPCSVZSSVZVIGE-UHFFFAOYSA-N

Gene Information

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This Item
27734P5585W283215
vibrant-m

P0500

Palmitic acid

-
vibrant-m

27734

Palmitic acid

-
vibrant-m

P5585

Palmitic acid

Premium Grade
vibrant-m

W283215

Palmitic acid

-
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

400

vapor pressure

10 mmHg ( 210 °C)

vapor pressure

10 mmHg ( 210 °C)

vapor pressure

10 mmHg ( 210 °C)

vapor pressure

10 mmHg ( 210 °C)

form

powder

form

flakes, powder or crystals

form

powder

form

crystals or chunks

bp

271.5 °C/100 mmHg (lit.)

bp

271.5 °C/100 mmHg (lit.)

bp

271.5 °C/100 mmHg (lit.)

bp

271.5 °C/100 mmHg (lit.)

storage temp.

room temp

storage temp.

-

storage temp.

room temp

storage temp.

-

General description

Palmitic acid (PA), a saturated fatty acid present in the human body, accounts for 20-30% of total fatty acids (FA) in membrane phospholipids (PL) and adipose triacylglycerols (TAG). It is one of the main components of palm oil however, significant amounts of PA are also found in meat and dairy products, cocoa butter, and olive oil. PA is also present in breast milk. PA performs various fundamental biological functions at cellular and tissue levels.

Application

Palmitic acid has been used:
  • to study its effects on monocyte chemoattractant protein-1 (MCP-1) expression in adipocytes and THP-1 macrophages
  • to stimulate lipotoxicity in primary rat hepatocytes
  • in Et-bovine serum albumin (BSA) solution along with retinoic acid (RA) and retinol to study its effects on spermatogenesis or meiotic progression

Storage Class

11 - Combustible Solids

wgk_germany

nwg

flash_point_f

235.4 °F

flash_point_c

113 °C

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Jorge Matias Caviglia et al.
Journal of lipid research, 52(9), 1636-1651 (2011-07-02)
Although short-term incubation of hepatocytes with oleic acid (OA) stimulates secretion of apolipoprotein B100 (apoB100), exposure to higher doses of OA for longer periods inhibits secretion in association with induction of endoplasmic reticulum (ER) stress. Palmitic acid (PA) induces ER
Songtao Li et al.
Biochimica et biophysica acta, 1841(1), 22-33 (2013-09-24)
Saturated fatty acids (SFAs) induce hepatocyte cell death, wherein oxidative stress is mechanistically involved. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master transcriptional regulator of cellular antioxidant defense enzymes. Therefore, Nrf2 activation is regarded as an effective strategy against
Chen Shen et al.
Journal of cellular and molecular medicine, 22(7), 3572-3581 (2018-04-20)
Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism(s) remain to be clearly elucidated. Toll-like receptor (TLR) 4 plays a fundamental role in activating the
Sanja Blaskovic et al.
The FEBS journal, 280(12), 2766-2774 (2013-04-05)
S-palmitoylation is post-translational modification, which consists in the addition of a C16 acyl chain to cytosolic cysteines and which is unique amongst lipid modifications in that it is reversible. It can thus, like phosphorylation or ubiquitination, act as a switch.
Jonas Sieber et al.
The American journal of pathology, 183(3), 735-744 (2013-07-23)
Type 2 diabetes mellitus is characterized by dyslipidemia with elevated free fatty acids (FFAs). Loss of podocytes is a hallmark of diabetic nephropathy, and podocytes are highly susceptible to saturated FFAs but not to protective, monounsaturated FFAs. We report that

Articles

Fatty acids of the n-3, n-6 and n-9 families are important supplements for cell culture systems. They are important in cell culture systems used to biomanufacture heterologous proteins, such as monoclonal antibodies.

How palmitic acid, other fatty acids and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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