This product is intended for research use only. Unfortunately, a pharmaceutical grade (±)-Propranolol hydrochloride product is not offered. Unless otherwise stated this product is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
P0884
(±)-Propranolol hydrochloride
≥99% (TLC), powder, β-adrenoceptor antagonist
Synonym(s):
(±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride, DL-Propranolol hydrochloride
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1 G
$51.90
5 G
$182.00
25 G
$724.00
100 G
$1,780.00
About This Item
Empirical Formula (Hill Notation):
C16H21NO2 · HCl
CAS Number:
Molecular Weight:
295.80
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
206-268-7
MDL number:
Beilstein/REAXYS Number:
4164259
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Product Name
(±)-Propranolol hydrochloride, ≥99% (TLC), powder
InChI key
ZMRUPTIKESYGQW-UHFFFAOYSA-N
InChI
1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H
SMILES string
Cl.CC(C)NCC(O)COc1cccc2ccccc12
assay
≥99% (TLC)
form
powder
color
white
solubility
ethanol: 10 mg/mL
DMSO: <14.5 mg/mL
H2O: 50 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
originator
AstraZeneca
storage temp.
2-8°C
Quality Level
Gene Information
human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358)
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Related Categories
1 of 4
This Item | 40543 | P-055 | BP1196 |
|---|---|---|---|
| form powder | form - | form liquid | form powder |
| assay ≥99% (TLC) | assay ≥98.5% (HPLC) | assay - | assay - |
| Quality Level 200 | Quality Level 100 | Quality Level 300 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility ethanol: 10 mg/mL, H2O: 50 mg/mL, DMSO: <14.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL | solubility - | solubility - | solubility - |
| originator AstraZeneca | originator - | originator - | originator - |
Application
Biochem/physiol Actions
Propranolol hydrochloride is a β-adrenoceptor antagonist. Its action at β2 receptor results in bronchoconstriction. Due to its lipophilic nature, propranolol can penetrate to the central nervous system and has a negative effect. It serves as a 5-HT1/5-HT2 serotonin receptor antagonist. Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris.[4] It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse.[5] It is known to competitively block the action of catecholamines.[5]
Disclaimer
Shelf-life of the solid is at least four years if stored protected from the uptake of moisture.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
Propranolol hydrochloride is easily soluble in ethanol and water.[4]
dissolve with heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Yuka Yagisawa et al.
PloS one, 15(7), e0236547-e0236547 (2020-07-28)
Occlusal disharmony leads to morphological changes in the hippocampus and osteopenia of the lumbar vertebra and long bones in mice, and causes stress. Various types of stress are associated with increased incidence of cardiovascular disease, but the relationship between occlusal
Sabrina Mai-Yi Fan et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(29), E6880-E6889 (2018-07-01)
Changes in external light patterns can alter cell activities in peripheral tissues through slow entrainment of the central clock in suprachiasmatic nucleus (SCN). It remains unclear whether cells in otherwise photo-insensitive tissues can achieve rapid responses to changes in external
Laxatives-Advances in Research and Application, 44-44 (2013)
Y Y Tan et al.
Journal of autonomic pharmacology, 15(6), 421-436 (1995-12-01)
1. The effect of long-term treatment with the beta-adrenoceptor antagonists (--)-tertatolol and (--)-propranolol was studied. Sprague-Dawley rats were treated with either (--)-tertatolol (50 micrograms kg-1 hr-1), (--)-propranolol (250 micrograms kg-1 hr-1) or vehicle (1 mM HCl) for 14 days with
Pharmaceutical Chemistry E-Book, 204-204 (2011)
Articles
DISCOVER Bioactive Small Molecules for Neuroscience
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Is this compound considered to be of pharmaceutical grade for use in animals?
1 answer-
Helpful?
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Bonjour, est-il possible de congeler une solution 10 mM de ce produit (P0884) en HBSS sans perte de ses propriétés moleculaires? Merci
1 answer-
Storing the solution at physiologic pH is not recommended, In aqueous solutions, propranolol decomposes with oxidation of the isopropylamine side-chain, accompanied by a reduction in pH and discoloration of the solution. Solutions of propranolol are most stable at pH 3. Propranolol decomposes rapidly in alkaline
solutions. Please see the link below to review a publication regarding the stability of this compound in solution:
https://academic.oup.com/ajhp/article-abstract/44/2/360/5196302?redirectedFrom=PDFHelpful?
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Could you please provide the solubility of product # P0884?
1 answer-
The chemical is soluble in water, ethanol, and DMSO. It is also soluble in (2-Hydroxypropyl)-β-cyclodextrin, making it compatible with in vitro and in vivo research. It is recommended to use C0926 in powder form or H5784 - (2-Hydroxypropyl)-β-cyclodextrin solution.
Helpful?
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What is the solution stability of the product P0884?
1 answer-
The solution stability of propranolol is as follows: In aqueous solutions, propranolol decomposes with oxidation of the isopropylamine side-chain, leading to a reduction in pH and discoloration of the solution. Solutions of propranolol are most stable at pH 3. According to Martindale references, propranolol decomposes rapidly in alkaline solutions.
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Is this compound a racemic mixture of the R and S enantiomers?
1 answer-
P0884 is a racemic mix of the D & L enantiomers of Propranolol hydrochloride.
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