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P1584

Sigma-Aldrich

Peptidyl Arginine Deiminase from rabbit skeletal muscle

buffered aqueous glycerol solution, ≥200 units/mg protein (Bradford)

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Synonym(s):
Protein arginine iminohydrolase
CAS Number:
75536-80-0
Enzyme Commission number:
3.5.3.15 (BRENDA, IUBMB)
MDL number:
MFCD00165226
NACRES:
NA.54

form

buffered aqueous glycerol solution

Quality Level

300

specific activity

≥200 units/mg protein (Bradford)

relevant disease(s)

arthritis (rheumatoid )

shipped in

dry ice

storage temp.

−70°C

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This Item
G2267L2500G8255
Peptidyl Arginine Deiminase from rabbit skeletal muscle buffered aqueous glycerol solution, ≥200 units/mg protein (Bradford)

Sigma-Aldrich

P1584

Peptidyl Arginine Deiminase from rabbit skeletal muscle

Glyceraldehyde-3-phosphate Dehydrogenase from rabbit muscle lyophilized powder, ≥75 units/mg protein

Sigma-Aldrich

G2267

Glyceraldehyde-3-phosphate Dehydrogenase from rabbit muscle

Sigma-Aldrich

Sigma-Aldrich

L2500

L-Lactic Dehydrogenase from rabbit muscle

Glutamic-Pyruvic Transaminase from porcine heart lyophilized powder, ≥75 units/mg protein

Sigma-Aldrich

G8255

Glutamic-Pyruvic Transaminase from porcine heart

specific activity

≥200 units/mg protein (Bradford)

specific activity

≥75 units/mg protein

specific activity

800-1,200 units/mg protein

specific activity

≥75 units/mg protein

shipped in

dry ice

shipped in

wet ice

shipped in

wet ice

shipped in

-

storage temp.

−70°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

relevant disease(s)

arthritis (rheumatoid )

relevant disease(s)

-

relevant disease(s)

-

relevant disease(s)

-

General description

Peptidyl arginine deiminase is the enzyme that converts arginine into citrulline.

Application

Peptidyl arginine deiminase has been used in a study that assessed promising novel biomarkers for the early diagnosis of rheumatoid arthritis. It has also been used in a study to investigate the autopathogenic correlation of periodontitis and rheumatoid arthritis.

Biochem/physiol Actions

Calcium is required for peptidylarginine deiminase activity in vitro.

Unit Definition

One unit will produce 1 μmole of N-α-benzoylcitrulline ethyl ester from BAEE per hr at 55 °C at pH 7.2.

Physical form

Solution in 20 mM Tris-HCl, pH 7.4, containing 10 mM 2-mercaptoethanol, 1 mM EDTA and 10% glycerol

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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25G
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Leendert A Trouw et al.
Autoimmunity reviews, 12(2), 318-322 (2012-06-06)
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and damage of the joints affecting about 0.5% of the general population. Early treatment in RA is important as it can prevent disease progression and irreversible damage of the
M Fujisaki et al.
Journal of biochemistry, 89(1), 257-263 (1981-01-01)
An enzyme which catalyzes the coversion of arginyl residues to citrullyl residues in protein was obtained from the extract of the epidermis of newborn rats. The enzyme required Ca2+ for its activity. The enzyme activity was enhanced in the presence
John G Routsias et al.
Rheumatology (Oxford, England), 50(7), 1189-1193 (2011-02-24)
Recently, a number of studies have pointed to a potential relationship between periodontitis (PO) and RA and vice versa. Both diseases are characterized by chronic inflammation, osseous destruction, damage of the supporting soft tissues, similar cellular immune responses and common
Murat Bozdag et al.
Bioorganic & medicinal chemistry letters, 23(3), 715-719 (2012-12-26)
Protein arginin deaminase 4 (PAD4) is a calcium dependent enzyme which catalyses the conversion of peptidyl-arginine into peptidyl-citrulline and is implicated in several diseases such as rheumatoid arthritis (RA) and cancer. Herein we report the discovery of novel small-molecule, non
Joyce J B C van Beers et al.
Biochimie, 95(2), 299-308 (2012-10-03)
Citrullination, the conversion of peptidylarginine to peptidylcitrulline is catalyzed by peptidylarginine deiminases (PAD). The expression of PAD isoforms displays great variation among different tissues as demonstrated by PAD mRNA analyses. Here we have analyzed the differential expression of PAD2, PAD4
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