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P1645

Sigma-Aldrich

Palmitoyl-L-carnitine chloride

≥98% (TLC), powder

Palmitoyl-L-carnitine chloride

Synonym(s):

O-Palmitoyl-L-carnitine chloride

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About This Item

Linear Formula:
C23H46NO4 · Cl
CAS Number:
Molecular Weight:
436.07
Beilstein/REAXYS Number:
4071005
EC Number:
MDL number:
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.25

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assay

≥98% (TLC)

form

powder

color

white

solubility

H2O: 25 mg/mL (with heat or sonication)

lipid type

saturated FAs

storage temp.

−20°C

SMILES string

[Cl-].CCCCCCCCCCCCCCCC(=O)O[C@H](CC(O)=O)C[N+](C)(C)C

InChI

1S/C23H45NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3;1H/t21-;/m1./s1

InChI key

GAMKNLFIHBMGQT-ZMBIFBSDSA-N

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This Item
P4509644323730920
assay

≥98% (TLC)

assay

≥98% (TLC)

assay

98% (CP)

assay

98% (CP)

form

powder

form

powder

form

solid

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

solubility

H2O: 25 mg/mL (with heat or sonication)

solubility

H2O: 25 mg/mL (with heat or sonication)

solubility

-

solubility

-

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

-

color

white

color

white

color

-

color

-

Application

Palmitoyl-L-carnitine chloride has been used as acylcarnitine in treating cardiomyocytes for the induction of reactive oxygen species (ROS).[1]

Biochem/physiol Actions

Long-chain acylcarnitine and well-known intermediate in mitochondrial fatty acid oxidation. Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart. Increases erythroid colony formation in culture. Reduces surface negative charge of erythrocytes and myocytes. Reported to affect currents and inhibit endothelium-dependent relaxation induced by acetylcholine and substance P in a dose-dependent manner by suppressing the intracellular calcium signal transduction in endothelial cells. Inhibits the Na/K pump current but has no effect on the intracellular calcium current in guinea pig ventricular cells. However, like oubain, it reversibly depolarizes the resting membrane, decreases action potential duration, and increases the amplitude of myocyte contractions.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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