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P2191

Sigma-Aldrich

Poly(D,L-lactide-co-glycolide)

lactide:glycolide (50:50), mol wt 30,000-60,000

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Synonym(s):
LACTEL® B6010-2, PLGA
Linear Formula:
[C3H4O2]x[C2H2O2]y
MDL number:
PubChem Substance ID:

feed ratio

lactide:glycolide (50:50)

mol wt

30,000-60,000

storage temp.

−20°C

SMILES string

OCC(O)=O.CC(O)C(O)=O

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This Item
P2066P1941805149
vibrant-m

P2191

Poly(D,L-lactide-co-glycolide)

vibrant-m

P2066

Poly(D,L-lactide-co-glycolide)

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P1941

Poly(D,L-lactide-co-glycolide)

vibrant-m

805149

PLGA nanoparticles

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

feed ratio

lactide:glycolide (50:50)

feed ratio

lactide:glycolide 65:35

feed ratio

lactide:glycolide (75:25)

feed ratio

-

mol wt

30,000-60,000

mol wt

Mw 40,000-75,000

mol wt

66,000-107,000

mol wt

-

General description

Poly(D,L-lactide-co-glycolide) is a biodegradable and biocompatible polymer, which is used for drug delivery. It is used to treat rheumatoid arthritis, ulcerative colitis, Crohn′s disease, inflammatory lung diseases and ophthalmic inflammatory disorders. Poly(D,L-lactide-co-glycolide) functions as a potential cancer therapeutic target.

application

Poly(D,L-lactide-co-glycolide) has been used to raise and sustain an increased lactate monomer level in the gel at a concentration relevant to dermal wounds.

Features and Benefits

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Physical form

Biocompatible, biodegradable polymer.

Legal Information

Lactel is a registered trademark of Evonik Corp

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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PLGA-based nanoparticles: an overview of biomedical applications
Danhier F, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 161(2), 505-522 (2012)
Characterization of biodegradable poly (D, L-lactide-co-glycolide) polymers and microspheres
Hausberger AG and DeLuca PP
Journal of Pharmaceutical and Biomedical Analysis, 13(6), 747-760 (1995)
Habibun Nabi et al.
Parasitology research, 116(1), 359-370 (2016-10-28)
Toxoplasmosis is one of the most common zoonotic protozoal diseases. Recent advances in biotechnology have produced recombinant protein, which are immunogenic, and progress in nano-pharmaceutics has generated encapsulated protein in nanospheres, which are suitable for vaccine delivery. DNA was extracted
Ahmed A Abd-Rabou et al.
Biological trace element research, 193(2), 377-389 (2019-05-09)
Colon cancer in men and breast cancer in women are regarded as major health burdens, accounting for majority of cancer diagnoses globally. Doxorubicin (DOX) resistance in breast and colon cancers represents the main reason of unsuccessful therapy. The rationale of
Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms
Hunt TK, et al.
Antioxidants & Redox Signaling, 9(8), 1115-1124 (2007)

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