P2508

Sigma-Aldrich

Proflavine hemisulfate salt hydrate

powder

Synonym(s):
3,6-Diaminoacridine hemisulfate salt
Empirical Formula (Hill Notation):
C13H11N3 · 0.5 H2SO4 · xH2O
CAS Number:
Molecular Weight:
258.29 (anhydrous basis)
Beilstein/REAXYS Number:
3921806
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

form

powder

Quality Level

application(s)

hematology: suitable
histology: suitable

solubility

H2O: 10 mg/mL

fluorescence

λex 444 nm; λem 508 nm (0.01M HCl)

Featured Industry

Diagnostic Assay Manufacturing

storage temp.

room temp

SMILES string

[H]O[H].OS(O)(=O)=O.Nc1ccc2cc3ccc(N)cc3nc2c1.Nc4ccc5cc6ccc(N)cc6nc5c4

InChI

1S/2C13H11N3.H2O4S.H2O/c2*14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;1-5(2,3)4;/h2*1-7H,14-15H2;(H2,1,2,3,4);1H2

InChI key

DTRLDKDFCPUGCA-UHFFFAOYSA-N

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General description

Proflavine is a small, amphipathic, acridine-derived fluorescent dye.Proflavine hemisulfate is used as a rapid stain for cytological studies of biological specimens. It stains cytoplasmic structures and nuclei. Proflavine has the capability to intercalate double stranded DNA.

Application

Proflavine hemisulfate salt hydrate has been used to stain cells of the 1483 cell line. It has also been used as a calibrating dye in fluorescence resonance energy transfer (FRET) analysis.

Packaging

1, 10, 25 g in glass bottle

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Emma V Ainsworth et al.
Chembiochem : a European journal of chemical biology, 17(24), 2324-2333 (2016-09-30)
The transfer of photoenergized electrons from extracellular photosensitizers across a bacterial cell envelope to drive intracellular chemical transformations represents an attractive way to harness nature's catalytic machinery for solar-assisted chemical synthesis. In Shewanella oneidensis MR-1 (MR-1), trans-outer-membrane electron transfer is...
Robust approaches to quantitative ratiometric FRET imaging of CFP/YFP fluorophores under confocal microscopy
M. R. Tadross
Journal of Microscopy (2009)
Proflavine Hemisulfate as a Fluorescent Contrast Agent for Point-of-Care Cytology
Sandra P. Prieto
PLoS ONE, 10(5) (2015)
A Orth et al.
Science advances, 5(4), eaav1555-eaav1555 (2019-04-30)
Optical fiber bundle microendoscopes are widely used for visualizing hard-to-reach areas of the human body. These ultrathin devices often forgo tunable focusing optics because of size constraints and are therefore limited to two-dimensional (2D) imaging modalities. Ideally, microendoscopes would record...
Improving spatial resolution of a fiber bundle optical biopsy system
Matthew Kyrish
Proceedings of SPIE (2010)
Protocols
Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.
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