P2870

Sigma-Aldrich

Pristane

synthetic, ≥98% (GC)

Synonym(s):
2,6,10,14-Tetramethylpentadecane
Linear Formula:
(CH3)2CH(CH2)3CH(CH3)(CH2)3CH(CH3)(CH2)3CH(CH3)2
CAS Number:
Molecular Weight:
268.52
Beilstein/REAXYS Number:
1720538
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

biological source

synthetic

assay

≥98% (GC)

refractive index

n20/D 1.438 (lit.)

bp

68 °C/0.001 mmHg (lit.)

density

0.783 g/mL at 20 °C (lit.)

SMILES string

CC(C)CCCC(C)CCCC(C)CCCC(C)C

InChI

1S/C19H40/c1-16(2)10-7-12-18(5)14-9-15-19(6)13-8-11-17(3)4/h16-19H,7-15H2,1-6H3

InChI key

XOJVVFBFDXDTEG-UHFFFAOYSA-N

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Application

Pristane has been used as an inflammation-inducing agent, leading to myeloma development in BALB/c strain mice. It has been used as a rheumatoid arthritis-inducing agent in rats.

Packaging

100, 250, 500 mL in glass bottle

Biochem/physiol Actions

Pristane is a hydrocarbon oil adjuvant widely used to induce tumorigenesis in mice and arthritis and lupus nephritis in rats. It works as a adjuvant for monoclonal antibody generation in mouse ascites.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

hazcat

Eye Irrit. 2 - Skin Irrit. 2

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 3

Flash Point(F)

230.0 °F - closed cup

Flash Point(C)

> 110 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Increased NHC Cells in the Peritoneal Cavity of Plasmacytoma Susceptible BALB/c Mouse.
Sanchez-Gonzalez B
Mediators of Inflammation, 2015, 313140-313140 (2015)
K Gadó et al.
Haematologica, 86(3), 227-236 (2001-03-20)
There is no ideal animal model for human multiple myeloma (MM). All the models resemble the human disease in some respect, but none of them fulfils all the criteria of a perfect animal model. The pristane oil (2,6,10,12-tetramethylpentadecane)-induced mouse plasmacytoma...
Acid-mediated reactions under microfluidic conditions: a new strategy for practical synthesis of biofunctional natural products.
Tanaka K and Fukase K
Beilstein Journal of Organic Chemistry, 5, 40-40 (2009)
M Satoh et al.
Clinical and experimental immunology, 121(2), 399-405 (2000-08-10)
Unlike other agents associated with drug-induced lupus, the isoprenoid alkane pristane induces autoantibodies pathognomonic of lupus, including anti-Sm, anti-dsDNA, and anti-ribosomal P in BALB/c and SJL/J mice. The susceptibility of other strains of mice to pristane-induced lupus is unknown and...
D A C Botte et al.
Clinical and experimental immunology, 177(2), 381-390 (2014-03-29)
Alpha-melanocyte stimulating hormone (α-MSH) is a neuropeptide exhibiting anti-inflammatory activity in experimental models of autoimmune diseases. However, no studies thus far have examined the effects of α-MSH on systemic lupus erythematosus (SLE). This study aimed to determine the effects of...
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