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P3032

Sigma-Aldrich

Penicillin G sodium salt

powder, BioReagent, suitable for cell culture

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Synonym(s):
Benzylpenicillin sodium salt
Empirical Formula (Hill Notation):
C16H17N2NaO4S
CAS Number:
Molecular Weight:
356.37
Beilstein:
3834217
EC Number:
MDL number:
eCl@ss:
34010400
PubChem Substance ID:
NACRES:
NA.76

product line

BioReagent

Quality Level

form

powder

potency

≥1477 units per mg

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 100 mg/mL (Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for extended periods. Solutions are stable at 37°C for 3 days.)

antibiotic activity spectrum

Gram-positive bacteria

Mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O

InChI

1S/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1

InChI key

FCPVYOBCFFNJFS-LQDWTQKMSA-M

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This Item
PENNA137521502701
Penicillin G sodium United States Pharmacopeia (USP) Reference Standard

USP

1502701

Penicillin G sodium

form

powder

form

powder

form

powder

form

-

potency

≥1477 units per mg

potency

-

potency

-

potency

-

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

-

solubility

H2O: 100 mg/mL (Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for extended periods. Solutions are stable at 37°C for 3 days.)

solubility

H2O: 100 mg/mL

solubility

-

solubility

-

antibiotic activity spectrum

Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

-

General description

Chemical structure: ß-lactam

Application

Penicillin G is a narrow spectrum natural antibiotic. It is effective against Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. It has been used to study the diagnostic and therapeutic implications of gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility and in cell culture both alone and combined with streptomycin and other antibiotics.

Biochem/physiol Actions

Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.

Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.

Caution

Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The sodium salt is soluble in H2O at 100 mg/mL.

Other Notes

1mu,10mu,25mu,100mu
Keep container tightly closed in a dry and well-ventilated place.Product contains Penicillin Keep in a dry place.

also commonly purchased with this product

Product No.
Description
Pricing

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

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Articles

Inhibition of Cell Wall Biosynthesis by Antibiotics

The specificity of β-lactam antibacterials is due to their ability to inhibit transpeptidase enzymes and prevent the assembly of the peptidoglycan layer in both Gram-positive and Gram-negative bacteria.

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