Skip to Content
MilliporeSigma

P3075

Phenylarsine oxide

synthetic (organic), ≥97%, tyrosine phosphatase inhibitor, powder

Synonym(s):

Arzene, Oxophenylarsine, PAO

Slide 1 of 3
Sign In to View Organizational & Contract Pricing.

Select a Size

1 G

$76.80

5 G

$263.00

$76.80

Check Cart for Availability
Request a Bulk Order

About This Item

Empirical Formula (Hill Notation):
C6H5AsO
CAS Number:
637-03-6
Molecular Weight:
168.02
NACRES:
NA.77
PubChem Substance ID:
24898387
UNSPSC Code:
12352119
EC Number:
211-275-3
MDL number:
MFCD00001990
Beilstein/REAXYS Number:
2935227

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Phenylarsine oxide, ≥97%, powder

InChI key

BQVCCPGCDUSGOE-UHFFFAOYSA-N

InChI

1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H

SMILES string

O=[As]c1ccccc1

biological source

synthetic (organic)

assay

≥97%

form

powder

color

white to off-white

mp

145-148 °C

solubility

DMSO: 50 mg/mL

Quality Level

100

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
521000-M18202882320
Phenylarsine oxide ≥97%, powder

Sigma-Aldrich

P3075

Phenylarsine oxide

Phenylarsine Oxide A membrane-permeable protein tyrosine phosphatase inhibitor (IC50 = 18 µM).

Millipore

521000-M

Phenylarsine Oxide

Poly(ethylene oxide) average Mv 600,000 (nominal), powder

Sigma-Aldrich

182028

Poly(ethylene oxide)

(±)-Propylene oxide puriss. p.a., ≥99.5% (GC)

Sigma-Aldrich

82320

(±)-Propylene oxide

form

powder

form

solid

form

powder

form

liquid

assay

≥97%

assay

≥96% (titration)

assay

-

assay

≥99.5% (GC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

solubility

DMSO: 50 mg/mL

solubility

chloroform: 100 mg/mL, DMSO: 50 mg/mL

solubility

-

solubility

-

color

white to off-white

color

white

color

-

color

-

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

Application

Phenylarsine oxide has been used to infuse animals with a nigrostriatal transection, to determine whether peroxovanadium (pVa) would synergize with brain-derived neurotrophic factor (BDNF).[1]

Biochem/physiol Actions

Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.
Phenylarsine oxide (PAO) can reduce the motility and sustainability of Setaria cervi.[2] It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.[3]

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Phenylarsine oxide (PhAsO4) is a bifunctional SH group chemical. It is hydrophobic in nature.[3]

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCX1623
MKCX2648
MKCV1404
MKCS0770
MKCQ0109

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Tyrosine phosphatase inhibition enhances neurotrophin potency and rescues nigrostriatal neurons in adult rats
Lu X, et al.
Experimental neurology, 178(2), 259-267 (2002)
M Wachtel et al.
Journal of cell science, 112 ( Pt 23), 4347-4356 (1999-11-24)
Regulation of epithelial and endothelial permeability is essential for proper function of compartmentalized organisms, and tyrosine phosphorylation plays an important role in this process. We analyzed the impact of protein tyrosine phosphatase (PTP) inhibition on the structure of endothelial junctional
Phenylarsine oxide induces the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria
Lenartowicz E, et al.
Journal of Bioenergetics and Biomembranes, 23(4), 679-688 (1991)
Inhibition of setaria cervi protein tyrosine phosphatases by phenylarsine oxide: A proteomic and biochemical study
Singh N, et al.
Acta Tropica, 159, 20-28 (2016)
Yao Xiao et al.
Nature plants, 6(5), 544-555 (2020-05-13)
The 3-phosphoinositide-dependent protein kinase 1 (PDK1) is a conserved master regulator of AGC kinases in eukaryotic organisms. pdk1 loss of function causes a lethal phenotype in animals and yeasts, but only mild phenotypic defects in Arabidopsis thaliana (Arabidopsis). The Arabidopsis genome
View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service