MilliporeSigma
All Photos(6)

Documents

P3088

Sigma-Aldrich

Monoclonal Anti-Parvalbumin antibody produced in mouse

clone PARV-19, ascites fluid

Sign Into View Organizational & Contract Pricing

Synonym(s):
Parvalbumin Antibody, Parvalbumin Antibody - Monoclonal Anti-Parvalbumin antibody produced in mouse
MDL number:
NACRES:
NA.44

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

PARV-19, monoclonal

mol wt

antigen 12 kDa

contains

15 mM sodium azide

species reactivity

fish, frog, rabbit, canine, feline, bovine, pig, human, goat, rat

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:2,000 using formalin-fixed, paraffin-embedded rat tongue or cerebellum sections
indirect ELISA: suitable
western blot: suitable

isotype

IgG1

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PVALB(5816)
rat ... Pvalb(25269)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SAB4200545C9848G3893
species reactivity

fish, frog, rabbit, canine, feline, bovine, pig, human, goat, rat

species reactivity

rat, human

species reactivity

mouse, human, guinea pig, canine, sheep, rat, pig, rabbit, feline, bovine, goat

species reactivity

rat, human, pig

antibody form

ascites fluid

antibody form

purified from hybridoma cell culture

antibody form

ascites fluid

antibody form

ascites fluid

clone

PARV-19, monoclonal

clone

PARV-19, monoclonal

clone

CB-955, monoclonal

clone

G-A-5, monoclonal

Gene Information

human ... PVALB(5816)
rat ... Pvalb(25269)

Gene Information

human ... PVALB(5816)
rat ... PVALB(25269)

Gene Information

human ... CALB1(793)
mouse ... Calb1(12307)
rat ... Calb1(83839)

Gene Information

human ... GFAP(2670)
rat ... Gfap(24387)

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

Still not finding the right product?  

Give our Product Selector Tool a try.

General description

PVALB (parvalbumin) is a classical small member of the low molecular weight, acidic protein family known as calcium binding proteins (CaBPs) EF-hand superfamily. This protein shows a restricted pattern of expression in brain and muscle. It is a cytoplasmic high affinity CaBP.
Monoclonal Anti-Parvalbumin (mouse IgG1 isotype) is derived from the PARV-19 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Parvalbumin is a calcium-binding protein.

Specificity

Recognizes parvalbumin in a Ca2+ ion-dependent manner. Does not react with other members of the EF-hand family such as calmodulin, intestinal calcium-binding protein, S100A2 (S100L), S100A6 (calcyclin), the α chain of S-100 (i.e. in S-100a and S-100ao), or the β chain (i.e. in S-100a and S-100b).

Immunogen

Frog muscle parvalbumin.

Application

Monoclonal Anti-Parvalbumin antibody produced in mouse has been used for immunohistochemistry, immunocytochemistry, and immunofluorescence.

Biochem/physiol Actions

PVALB (parvalbumin) protein modulates relaxation in fast contracting muscles, where it localizes to type II (fast-twitch) mammalian skeletal muscle fibres in small mammals. This protein is a crucial regulator of neuronal intracellular calcium dynamics. PVALB protein maintains synaptic transmission during bursts, where it prevents presynaptic Ca2+ accumulation and hence the harmful effects of excess presynaptic Ca2+ levels. It also maintains synaptic transmission by allowing for linear information processing post-synaptically by preventing cumulative neuronal facilitation.

PVALB (parvalbumin) expression serves as marker for differentiating tumors as benign and malignant, in relation with thyroid lesions. Decreased expression of parvalbumin positive interneurons in rat model is associated with schizophrenia, and is known to disturb neuronal activity.

Physical form

Liquid

Storage and Stability

For continuous use, store at 2-8 °C for up to one month.
For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Aging-related changes in calcium-binding proteins in rat perirhinal cortex
Moyer Jr J R, et al.
Neurobiology of Aging, 32(9), 1693-1706 (2011)
A loss of parvalbumin-containing interneurons is associated with diminished oscillatory activity in an animal model of schizophrenia.
Lodge DJ, et al.
The Journal of Neuroscience, 29(8), 2344-2354 (2009)
Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression.
Liu Z et al
The Journal of Neuroscience, 32(19), 6600-6610 (2012)
Parvalbumin in most gamma-aminobutyric acid-containing neurons of the rat cerebral cortex.
Celio MR
Science, 231(4741), 995-997 (1986)
Nobutake Hosoi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(32), 6339-6353 (2019-06-16)
ADP-ribosylation factors (ARFs) are a family of small monomeric GTPases comprising six members categorized into three classes: class I (ARF1, 2, and 3), class II (ARF4 and 5), and class III (ARF6). In contrast to class I and III ARFs

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service