The surface charge and empirical formula of this product hve not been determined. Please see the link below to review a publication that may be of interest:
https://pmc.ncbi.nlm.nih.gov/articles/PMC323473/
P3235
Prostate Specific Antigen from human semen
buffered aqueous solution
Synonym(s):
Cancer-associated PSA, PSA
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10 μG
$327.00
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About This Item
Form:
buffered aqueous solution
Assay:
≥99% (SDS-GE)
Biological source:
human semen
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biological source
human semen
assay
≥99% (SDS-GE)
form
buffered aqueous solution
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... KLK3(354)
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This Item | P3338 | SRP6058 | P3360 |
|---|---|---|---|
| assay ≥99% (SDS-GE) | assay - | assay ≥95% (SDS-PAGE) | assay ≥99% (SDS-PAGE) |
| biological source human semen | biological source - | biological source human | biological source human |
| form buffered aqueous solution | form - | form lyophilized | form buffered aqueous solution |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −70°C | storage temp. −20°C |
| UniProt accession no. | UniProt accession no. | UniProt accession no. - | UniProt accession no. |
| Gene Information human ... KLK3(354) | Gene Information human ... KLK3(354) | Gene Information human ... KLK3(354) | Gene Information human ... KLK3(354), SERPINA3(12) |
General description
Biochem/physiol Actions
Glycoprotein of the glandular kallikrein family
Prostate Specific Antigen (PSA), a glycoprotein of the glandular kallikrein family, is a serine protease with chymotrypsin-like enzymatic activity. Circulating PSA exists in free and protease inhibitor-bound forms. Studying the ratios of free to inhibitor-bound forms may prove valuable in the diagnosis of prostate cancer.
Prostate-specific antigen (PSA) is an androgen-regulated serine protease specifically produced by prostatic tissue and is secreted into the lumen. PSA in semen cleaves semenogelins present in the seminal coagulum. Total PSA levels are increased in serum of prostate cancer (PCa) patients. PSA functions as a potential biomarker for PCa.[3][2] Serum protease inhibitors such as α1-antichymotrypsin (α1-ACT), α2-macroglobulin (α2-M) and other acute-phase proteins form irreversible complexes with circulating PSA and hinder proteolytic activity of PSA.[4]
Physical form
Solution in 10 mM Tris, 0.1% sodium azide, pH 8.0
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Structure, function, and regulation of the enzyme activity of prostate-specific antigen.
Lilja H
World Journal of Urology, 11(4), 188-191 (1993)
Qian Dang et al.
Analytical and bioanalytical chemistry, 408(25), 7067-7075 (2016-03-05)
A simple and sensitive electrogenerated chemiluminescence biosensor was developed to monitor matrix metalloproteinase 2 (MMP-2) by employing a specific peptide (CGPLGVRGK) as a molecular recognition substrate. Bis(2,2'-bipyridine)-4'-methyl-4-carboxybipyridine-ruthenium N-succinimidyl ester-bis(hexafluorophosphate) (Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 (Ru1) was used as ECL-emitting species and covalently labeled onto
Multiple forms of prostate-specific antigen in serum: differences in immunorecognition by monoclonal and polyclonal assays.
Zhou AM
Clinical Chemistry, 39(12), 2483-2491 (1993)
Steven P Balk et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 21(2), 383-391 (2003-01-15)
Prostate-specific antigen (PSA) is an androgen-regulated serine protease produced by both prostate epithelial cells and prostate cancer (PCa) and is the most commonly used serum marker for cancer. It is a member of the tissue kallikrein family, some of the
D A Armbruster
Clinical chemistry, 39(2), 181-195 (1993-02-01)
Prostate-specific antigen (PSA) is a glycoprotein produced exclusively by prostatic tissue. PSA's absolute tissue specificity makes it valuable as a forensic marker and, more important, as a tumor marker for prostatic cancer. Prostatic cancer is prevalent in the older male
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Hello, I would like to get some information about PSA Antigen from human semen. What is the surface charge and could you send the Empirical Formula.
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