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P3326

Sigma-Aldrich

Platelet-Derived Growth Factor-AB human

≥97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

PDGF-AB

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$367.00
50 μG
$1,170.00

About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77

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$367.00


In StockDetails


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Product Name

Platelet-Derived Growth Factor-AB human, PDGF-AB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE and N-terminal analysis)

form

lyophilized powder

potency

10-100 ng/mL ED50/EC50

quality

endotoxin tested

mol wt

27-31 kDa

packaging

pkg of 10 μg
pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

UniProt accession no.

storage temp.

−20°C

Gene Information

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This Item
P3201P8953P4056
biological source

human

biological source

human

biological source

Porcine

biological source

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

-

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE and N-terminal analysis)

assay

≥98% (HPLC and SDS-PAGE)

assay

≥97% (SDS-PAGE and N-terminal analysis)

assay

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

General description

Platelet-Derived Growth Factor (PDGF) is a cationic polypeptide and a constituent of α-granules. PDGF is composed of chain A and B linked together by a disulphide bridge.[1] PDGF heterodimers occurs as PDGF-AB and homodimers exists as FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD).[2] The PDGFB gene is localized to pericytes in the brain and is mapped to human chromosome 7p22.3.[3][4]

Application

Platelet-Derived Growth Factor-AB human has been used in luciferase reporter assay.[5]

Biochem/physiol Actions

Cellular actions of platelet-derived growth factor (PDGF) include chemoattraction and activation of neutrophils, monocytes, and fibroblasts.[6] PDGF appears to play a crucial role in the cellular response to tissue injury and is critically involved in the pathological progression of atherosclerosis.
PDGF stimulates fibroblast proliferation and extracellular matrix production in order to facilitate tissue repair.[7] PDGF-AB isomer is found to be associated with angiogenesis and proliferation.[8] Loss of PDGFB gene function induces microvascular calcification due to age-dependent phenotypical changes.[3]

Other Notes

Heterodimer of the A and B chains of PDGF disulfide linked.

Physical form

Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid.

Analysis Note

The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in quiescent NR6R-3T3 fibroblasts.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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