Monoclonal Anti-PTEN antibody produced in mouse

~1 mg/mL, purified immunoglobulin, clone PTN-18, buffered aqueous solution

MDL number:

Quality Level

biological source


antibody form

purified immunoglobulin

antibody product type

primary antibodies


PTN-18, monoclonal


buffered aqueous solution

mol wt

antigen ~55 kDa

species reactivity

mouse, rat, human


~1 mg/mL


immunocytochemistry: suitable using 4% paraformaldehyde-0.5% Triton X-100 fixation
indirect ELISA: suitable
microarray: suitable
western blot: 5-10 μg/mL using whole extract of rat brain





UniProt accession no.

shipped in

dry ice

storage temp.


Gene Information

human ... PTEN(5728)
mouse ... Pten(19211)
rat ... Pten(50557)

General description

The PTEN (phosphatase and tensin homolog) gene is mapped to human chromosome 10q23. It shares sequence homology with protein tyrosine phosphatases and the cytoskeletal protein tensin.


The epitope recognized by the antibody resides within amino acids 386-403 of rat PTEN.


synthetic peptide corresponding to the C-terminus of rat PTEN (amino acids 386-403).

Biochem/physiol Actions

The PTEN (phosphatase and tensin homolog) gene encodes a encodes a dual-specificity phosphatase that functions as a tumor suppressor by inhibiting phosphoinositide-3-kinase–protein kinase B/Akt (PI3K/PKB/Akt) signaling pathway, a crucial regulator of cell growth and survival and by negatively regulating the interactions of cell with the extracellular matrix. Mutations in this gene have been associated with several human cancers. Germline mutations in this gene have also been linked to Cowden disease (CD), Lhermitte-Duclos disease (LDD) and Bannayan-Zonana syndrome (BZS), which are characterized by increased susceptibility to tumor formation and developmental defects.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
Li J, et al.
Science, 275(5308), 1943-1947 (1997)
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN.
Tamura M, et al.
Science, 280(5369), 1614-1617 (1998)
Pten is essential for embryonic development and tumour suppression.
Di Cristofano A, et al.
Nature Genetics, 19(4), 348-355 (1998)
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.
Stambolic V, et al.
Cell, 95(1), 29-39 (1998)
Hong Lu et al.
Oncology letters, 17(1), 69-72 (2019-01-19)
The expression pattern of tumor suppressor gene phosphatase and tensin homolog deleted on chromosome ten (PTEN) and phosphatase and tensin homolog deleted on chromosome ten/phosphatidylinositol3-kinase/protein kinase B (PTEN/PI3K/AKT) cell signaling pathway in renal cell carcinoma (RCC) were investigated in children....
Quantitative and qualitative western blotting to validate knockdown by esiRNA.
Read More
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
Read More

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.