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P3635

Sigma-Aldrich

5β-Pregnane-3α,20α-diol glucuronide

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Synonym(s):
P3G, PDG, Pn3-G, Pregnanediol-3a-glucuronide, Pregnanediol-glucuronide, 3α,20α-Dihydroxy-5β-pregnane 3-glucuronide
Empirical Formula (Hill Notation):
C27H44O8
CAS Number:
Molecular Weight:
496.63
MDL number:
PubChem Substance ID:
NACRES:
NA.77

sterility

non-sterile

assay

≥98.00% (TLC)

form

powder

technique(s)

enzyme immunoassay: suitable

solubility

ethanol: 20 mg/mL, clear, colorless

shipped in

ambient

storage temp.

−20°C

SMILES string

CC(O)C1CCC2C3CCC4CC(CCC4(C)C3CCC12C)OC5OC(C(O)C(O)C5O)C(O)=O

InChI

1S/C27H44O8/c1-13(28)17-6-7-18-16-5-4-14-12-15(8-10-26(14,2)19(16)9-11-27(17,18)3)34-25-22(31)20(29)21(30)23(35-25)24(32)33/h13-23,25,28-31H,4-12H2,1-3H3,(H,32,33)

InChI key

ZFFFJLDTCLJDHL-UHFFFAOYSA-N

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P8629

5β-Pregnane-3α,17α,20α-triol

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P8129

5β-Pregnan-3α-ol-20-one

vibrant-m

P5052

5α-Pregnan-3α-ol-11,20-dione

assay

≥98.00% (TLC)

assay

≥98.00% (TLC)

assay

≥98% (TLC)

assay

≥98% (TLC)

technique(s)

enzyme immunoassay: suitable

technique(s)

-

technique(s)

-

technique(s)

-

storage temp.

−20°C

storage temp.

room temp

storage temp.

room temp

storage temp.

-

solubility

ethanol: 20 mg/mL, clear, colorless

solubility

chloroform: methanol (1:1): 19.60-20.40 mg/mL, clear, colorless

solubility

chloroform: 50 mg/mL, clear, colorless

solubility

chloroform: ≥5 mg/mL, clear, colorless

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

-

General description

5β-Pregnane-3α,20α-diol glucuronide is a progesterone metabolite predominant in urine, during pregnancy. Presence of 5β-Pregnane-3α,20α-diol glucuronide in the urine indicates pregnancy, but it might also account for pseudopregnancy. It is useful in predicting the delivery time/end of pseudopregnancy.
Urinary pregnanediol glucuronide (PdG) seems to serve as an effective clinical marker for monitoring progesterone supplementation. PdG, along with other urinary metabolites such as luteinizing hormone (LH), follicle stimulating hormone (FSH), and estrone glucuronide (ElG), exhibit a strong association with ovarian excretion rates and demonstrate a high correlation with serum reproductive hormones. As a result, they can be used interchangeably to effectively monitor ovarian steroidogenesis.

Application

5β-Pregnane-3α,20α-diol glucuronide has been used in a cross-sectional analysis of hormone levels. It has also been used as a standard to measure estradiol-17β, pregnanediol-glucuronide (PdG) by a double-antibody enzyme immunoassay.
5β-Pregnane-3α,20α-diol glucuronide has been used in steroid enzyme immunoassay.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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