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Pyridoxal 5′-phosphate hydrate

Name: Pyridoxal 5′-phosphate hydrate
Brand: SIGMA
Price: 92.8 USD
Availability: InStock

powder, BioReagent, suitable for cell culture

Synonym(s):

3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde, Codecarboxylase, PLP, Pyridoxal 5-phosphate

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Pack Size	SKU	Availability	Price
1 g		Available to ship TODAYfromMILWAUKEE	$92.80

About This Item

Empirical Formula (Hill Notation):

C₈H₁₀NO₆P · xH₂O

CAS Number:

853645-22-4

Molecular Weight:

247.14 (anhydrous basis)

UNSPSC Code:

12352205

NACRES:

NA.75

PubChem Substance ID:

24898438

EC Number:

200-208-3

Beilstein/REAXYS Number:

234749

MDL number:

MFCD00006333

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Properties

product line

BioReagent

Quality Level

200

assay

≥98%

form

powder

mol wt

M_w 247.14 g/mol

technique(s)

cell culture | mammalian: suitable

color

off-white to yellow-brown

mp

140-143 °C

solubility

1 M HCl: soluble 50 mg/mL, clear, colorless to light yellow-green

storage temp.

−20°C

SMILES string

CC1=NC=C(COP(O)(O)=O)C(C([H])=O)=C1O

InChI

1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)

InChI key

NGVDGCNFYWLIFO-UHFFFAOYSA-N

Description

General description

Pyridoxal-phosphate (PLP, pyridoxal-5′-phosphate, P5P) is a prosthetic group of some enzymes. It is the active form of vitamin B6, which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine. PLP acts as a coenzyme in all transamination reactions, and in some decarboxylation and deamination reactions of amino acids.

Application

Hierarchical Surface Architecture of Hemodialysis Membranes for Eliminating Homocysteine Based on the Multifunctional Role of Pyridoxal 5′-phosphate.: Discusses the development of advanced hemodialysis membranes using pyridoxal 5′-phosphate, highlighting its role in reducing homocysteine levels, which could contribute to improved outcomes for dialysis patients (Jiang P et al., 2020).

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This Item	P9255	82870	P6155
Sigma-Aldrich P3657 Pyridoxal 5′-phosphate hydrate	Sigma-Aldrich P9255 Pyridoxal 5′-phosphate hydrate	Sigma-Aldrich 82870 Pyridoxal 5′-phosphate monohydrate	Sigma-Aldrich P6155 Pyridoxal hydrochloride
technique(s) cell culture \| mammalian: suitable	technique(s) HPLC: suitable	technique(s) enzyme immunoassay: suitable	technique(s) cell culture \| insect: suitable, cell culture \| mammalian: suitable
assay ≥98%	assay ≥98%	assay ≥97.0% (NT)	assay ≥99% (HPLC)
form powder	form powder	form powder	form powder
solubility 1 M HCl: soluble 50 mg/mL, clear, colorless to light yellow-green	solubility -	solubility -	solubility water: soluble 50 mg/mL, clear, colorless to light greenish-yellow
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
color off-white to yellow-brown	color beige, off-white to yellow	color white to light yellow	color white to off-white

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

Vitamin B6, Pyridoxal and Pyridoxine in Cell Culture

Vitamin B6's impact on serum-free cell culture systems is explored for protein manufacturing.

'Click chemistry' synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase.

Ivone Carvalho et al.

Bioorganic & medicinal chemistry, 18(7), 2412-2427 (2010-03-26)

Trypanosoma cruzi trans-sialidase (TcTS) plays a key role in the recognition and invasion of host cells and in enabling the parasite to escape the human immune response. To explore this potential drug target, we have synthesized a small library of

The Drosophila Pericentrin-like-protein (PLP) cooperates with Cnn to maintain the integrity of the outer PCM.

Jennifer H Richens et al.

Biology open, 4(8), 1052-1061 (2015-07-15)

Centrosomes comprise a pair of centrioles surrounded by a matrix of pericentriolar material (PCM). In vertebrate cells, Pericentrin plays an important part in mitotic PCM assembly, but the Drosophila Pericentrin-like protein (PLP) appears to have a more minor role in

Multifaceted innate immune responses engaged by astrocytes, microglia and resident dendritic cells against Chikungunya neuroinfection.

Trina Das et al.

The Journal of general virology, 96(Pt 2), 294-310 (2014-10-30)

Chikungunya virus (CHIKV) has recently affected millions of people in the Indian Ocean, with rare cases of encephalopathy and encephalitis occurring in neonates. In the study described herein, the capacity of mouse brain cells to control infection through innate immune

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Global Trade Item Number

SKU	GTIN
P3657-1G	04061834372752

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