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P4365

PJ-34 hydrochloride hydrate

≥98% (HPLC), powder

Synonym(s):

PARP Inhibitor VIII, PJ 34 HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride

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Pack SizeSKUAvailabilityPrice
5 mg

Available to ship onApril 08, 2026fromMILWAUKEE

$319.00
$271.15

About This Item

Empirical Formula (Hill Notation):
C17H17N3O2 · HCl · xH2O
CAS Number:
344458-15-7
Molecular Weight:
331.80 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24898531
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to yellow

solubility

H2O: 22 mg/mL

SMILES string

Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1

InChI

1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2

InChI key

YCALIZUKAFUQCH-UHFFFAOYSA-N

Application

PJ-34 hydrochloride hydrate has been used:
  • as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain[1]
  • as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples[2]
  • as PARP inhibitor in murine MLE-12 epithelial cell line[3]

Biochem/physiol Actions

PJ-34 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor.
PJ-34 is a prototypic poly(ADP-ribose) polymerase 1 (PARP-1) inhibitor.[3]

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This Item
528151528150M9656
PJ-34 hydrochloride hydrate ≥98% (HPLC), powder

Sigma-Aldrich

P4365

PJ-34 hydrochloride hydrate

PARP Inhibitor VIII, PJ34 InSolution, ≥98%

Sigma-Aldrich

528151

PARP Inhibitor VIII, PJ34

PARP Inhibitor VIII, PJ34 The PARP Inhibitor VIII, PJ34, also referenced under CAS 344458-15-7, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

Sigma-Aldrich

528150

PARP Inhibitor VIII, PJ34

H-8 dihydrochloride >98% (HPLC)

Sigma-Aldrich

M9656

H-8 dihydrochloride

form

powder

form

liquid

form

solid

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

>98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

solubility

H2O: 22 mg/mL

solubility

-

solubility

water: 5 mg/mL

solubility

-

storage condition

desiccated

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

-

color

white to yellow

color

-

color

white

color

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000174914
0000174914
0000113076
0000069854
0000015950

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Yan Gao et al.
Brain, behavior, and immunity, 88, 482-496 (2020-04-14)
Emerging evidence has implicated poly-(ADP-ribose) polymerase 1 (PARP-1), a transcriptional coregulator, in a variety of inflammatory diseases. In the current study, the role of PARP-1 in neuropathic pain and the underlying mechanisms were investigated. Neuropathic pain was determined by assessing
Hai-yan Li et al.
Acta pharmacologica Sinica, 35(4), 496-503 (2014-03-19)
Daidzein (4',7-dihydroxyisoflavone) is an isoflavone exiting in many herbs that has shown anti-inflammation activity. The aim of this study was to investigate the mechanism underlying its anti-inflammatory action in murine lung epithelial cells. C57BL/6 mice were intranasally exposed to TNF-α
Garcia Soriano F et al.
Nature medicine, 7(1), 108-113 (2001-01-03)
Diabetic patients frequently suffer from retinopathy, nephropathy, neuropathy and accelerated atherosclerosis. The loss of endothelial function precedes these vascular alterations. Here we report that activation of poly(ADP-ribose) polymerase (PARP) is an important factor in the pathogenesis of endothelial dysfunction in
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Global Trade Item Number

SKUGTIN
P4365-5MG04061834374428

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