P4405

Podophyllotoxin

• Empirical Formula (Hill Notation): C₂₂H₂₂O₈
• CAS Number: 518-28-5
• Molecular Weight: 414.41
• Beilstein/REAXYS Number: 99163
• EC Number: 208-250-4
• MDL number: MFCD00075290
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277731
• NACRES: NA.77

Properties

• assay: ≥98%
• Quality Level: 200
• form: powder
• mp: 183-184 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: COc1cc(cc(OC)c1OC)[C@H]2C3C(COC3=O)[C@@H](O)c4cc5OCOc5cc24
• InChI: 1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
• InChI key: YJGVMLPVUAXIQN-XVVDYKMHSA-N

Description

Application

Podophyllotoxin has been used as a reference compound for evaluating the cytotoxicity in VERO cells.[1][2] It has also been used as a reference standard in high-performance liquid chromatography (HPLC).[3]

Biochem/physiol Actions

Inhibits microtubule assembly; antineoplastic.

Podophyllotoxin is a naturally occurring lignan obtained from resin podophyllin present in the genus Podophyllum.[4] It exhibits antiviral[5] and antimitotic properties.[6][5] Podophyllotoxin may be used to treat anogenital warts in children and dermatological conditions caused by psoriasis vulgaris. It may also be used as a therapeutic agent to treat genital tumors, Wilms tumors, lung cancer, and lymphomas.[4]

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311 + H331,H315,H319,H335
• pcodes: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges