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Pravastatin sodium salt hydrate

≥98% (HPLC), powder

R, δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β, δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic acid sodium hydrate, Eptastatin sodium salt hydrate
Empirical Formula (Hill Notation):
C23H35O7Na · xH2O
CAS Number:
Molecular Weight:
446.51 (anhydrous basis)
MDL number:
PubChem Substance ID:

biological source

synthetic (organic)

Quality Level


≥98% (HPLC)






171.2-173 °C


H2O: >10 mg/mL


Bristol-Myers Squibb

storage temp.


SMILES string




InChI key


Gene Information

human ... HMGCR(3156)

General description

Pravastatin sodium is an orally effective hypocholesterolaemic agent which is structurally similar to lovastatin and compactin.


Pravastatin sodium salt hydrate has been used in the enzymatic method to measure mevalonic acid in serum.


25 mg in glass bottle

Biochem/physiol Actions

Pravastatin sodium is a competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
Competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Inhibits cholesterol synthesis in vivo (Ki ~1 nM).

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

13 - Non Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

Tsuyoshi Nozue et al.
The American journal of cardiology, 111(10), 1415-1419 (2013-02-26)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of serum low-density lipoprotein cholesterol levels. Although statins increase serum PCSK9 levels, the effects of different types of statins on the serum PCSK9 levels have not been examined in detail.
Sylvain Glitho et al.
La Revue du praticien, 63(5), 626-626 (2013-06-26)
S P Mooijaart et al.
Journal of internal medicine, 274(1), 77-85 (2013-02-19)
Inflammation is involved in the pathogenesis of cardiovascular disease and cognitive decline. Interleukin-6 (IL-6) has a role in cardiovascular disease, but the association of IL-6 concentration and the functional IL-6 -174 polymorphism with cognitive decline has not been demonstrated unequivocally.
Drug development for progeria yields insights into normal aging.
Kevin Jiang
Nature medicine, 19(5), 515-515 (2013-05-09)
Tsutomu Yamazaki et al.
International heart journal, 54(1), 33-39 (2013-02-23)
This paper describes a subanalysis of the JART Study comparing rosuvastatin and pravastatin treatment. A total of 314 subjects were analyzed in this subanalysis, 282 of whom were eligible for evaluation of the relationship between LDL-C and carotid mean-IMT change.


Cholesterol Biosynthesis Regulation

The amount of cholesterol that is synthesized in the liver is tightly regulated by dietary cholesterol levels. LDL receptors regulate the cellular transport of lipid rich low density lipoprotein (LDL) particles.

Dietary Terpenes

Terpenes comprise the largest and most diverse class of secondary metabolites; approximately 55,000 compounds have been identified to date.

Antilipemic Agents

Randomized controlled clinical studies have suggested 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are effective in both primary and secondary prevention of cardiovascular disease (CVD) events.

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