P4543

Sigma-Aldrich

Valproic acid sodium salt

98%

Synonym(s):
2-propylpentanoic acid sodium, Sodium 2-propylpentanoate, Sodium valproate
Empirical Formula (Hill Notation):
C8H15NaO2
CAS Number:
Molecular Weight:
166.19
EC Number:
MDL number:
eCl@ss:
42020819
PubChem Substance ID:

Quality Level

assay

98%

solubility

H2O: 50 mg/mL

originator

Abbott

SMILES string

[Na+].CCCC(CCC)C([O-])=O

InChI

1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1

InChI key

AEQFSUDEHCCHBT-UHFFFAOYSA-M

Gene Information

human ... ALDH5A1(7915)

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Application

Valproic acid sodium salt has been used:
  • in resazurin viability assay
  • to systematically study its effects of clinical doses on brain volume and offspring behavior
  • to study its effect on atherosclerotic lesion size

Packaging

10, 25, 100 g in glass bottle

Biochem/physiol Actions

Valproic acid is an anticonvulsant and mood-stabilizing drug. It is used to treat epilepsy and bipolar disorder. Valproic acid helps to repress the Warburg effect and the development of tumor in neuroblastoma.
Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Pictograms

Exclamation markHealth hazard

Signal Word

Warning

Hazard Statements

hazcat

Acute Tox. 4 Oral - Repr. 2

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

The pharmacogenomics of valproic acid
Zhu M, et al.
Journal of Human Genetics, 62(12), 1009-1009 (2017)
Glucosamine-supplementation promotes endoplasmic reticulum stress, hepatic steatosis and accelerated atherogenesis in apoE-/- mice
Beriault D R, et al.
Atherosclerosis, 219(1), 134-140 (2011)
Valproic acid suppresses Warburg effect and tumor progression in neuroblastoma
Fang E, et al.
Biochemical and biophysical research communications (2018)
Dose-dependent memory effects and cerebral volume changes after in utero exposure to valproate in the rat
Frisch C H, et al.
Epilepsia, 50(6), 1432-1441 (2009)
Erik Taubøll et al.
Epilepsia, 50(8), 1868-1874 (2009-06-06)
Recent animal studies have indicated possible reproductive endocrine effects of levetiracetam (LEV). The aim of the present study was to investigate possible reproductive endocrine effects of LEV compared to valproate (VPA) using human ovarian follicular cells. Cell cultures of human...
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