This product has a phosphate group at the 5' end. No information is available regarding the ability of this product to be sensed by cellular RNA sensors.
P4903
poly(C)
Synonym(s):
Polycytidylic acid potassium salt, Poly(C) potassium salt
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10 MG
$109.00
25 MG
$216.00
100 MG
$543.00
About This Item
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Related Categories
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This Item | P9403 | P9528 | P9827 |
|---|---|---|---|
| Quality Level 200 | Quality Level 300 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form lyophilized powder | form lyophilized powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Preparation Note
Prepared from CDP using polynucleotide phosphorylase
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Adalena V Nanni et al.
RNA biology, 15(9), 1181-1191 (2018-09-04)
Epstein-Barr virus (EBV) expresses an abundant nuclear noncoding RNA called EBER2, which interacts with and acts as a guide RNA for the host transcription factor PAX5. This ribonucleoprotein complex localizes to the terminal repeat (TR) regions of the EBV genome
Kang Xu et al.
Developmental and comparative immunology, 99, 103410-103410 (2019-06-09)
As a member of NDR protein kinase family and a novel protein kinase of Hippo signal pathway, Serine/threonine kinase 38 (STK38) plays a very significant role in the innate immune. In mammals, STK38 performs its function by combining with GSK3β.
Christina Kwong et al.
Oncoimmunology, 2(1), e22978-e22978 (2013-03-14)
The vacuolar ATPase (V-ATPase) plays an important role in tumor progression and metastases. A novel peptide from the a2 isoform of V-ATPase called a2NTD has been shown to exert an immunoregulatory role in the tumor microenvironment by controlling the maturation
Dongrong Yi et al.
Frontiers in microbiology, 11, 1440-1440 (2020-07-17)
All RNA viruses encode the RNA-dependent RNA polymerase (RdRp) which replicates and transcribes viral RNA. This essential viral enzyme does not exist in mammalian cells, thus presents a main target for the development of antiviral drugs with potential pan-antiviral activity.
Jordina Guillén-Boixet et al.
Cell, 181(2), 346-361 (2020-04-18)
Stressed cells shut down translation, release mRNA molecules from polysomes, and form stress granules (SGs) via a network of interactions that involve G3BP. Here we focus on the mechanistic underpinnings of SG assembly. We show that, under non-stress conditions, G3BP
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What structure is on the 5' end of this RNA (5' monophosphate?) and is this known to be sensed by any cellular RNA sensors?
1 answer-
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What would be the ideal buffer to dissolve the poly(C) in for ideal long-term storage?
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The solubility of this product is tested in water at approximately 20 mg/mL. The solubility has not been tested in a buffer solution. However, the Polyuridylic acid potassium salt, P9528, offers a datasheet that notes the material may not be completely soluble in Tris buffer at 1 mg/mL.
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What is the size range? How many nucleotides per molecule?
1 answer-
Unfortunately, the particle size range and nucleotides number are not tested as per the COA of P4903: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/P4903-100MG0000303636.pdf
There is a reference value for degree of polymerization (DP) available to roughly estimate the nucleotides number, which is ~485. The value could vary lot by lot.Helpful?
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