P5235

Sigma-Aldrich

Anti-Presenilin-1 (14-33) antibody produced in goat

whole antiserum

MDL number:
NACRES:
NA.41

Quality Level

biological source

goat

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

contains

0.1% sodium azide

species reactivity

human

application(s)

immunohistochemistry: suitable

conjugate

unconjugated

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... PSEN1(5663)

Immunogen

amino acids 14-33 of presenilin 1

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Germany

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Certificate of Analysis
Certificate of Origin
G M Murphy et al.
The American journal of pathology, 149(6), 1839-1846 (1996-12-01)
Mutations in the presenilin (PS)-1 and PS-2 genes have been shown to be linked with the development of Alzheimer's disease (AD). We examined Alzheimer's brain tissue by immunohistochemistry using a set of antibodies raised to sequences shared between PS-1 and...
R Sherrington et al.
Nature, 375(6534), 754-760 (1995-06-29)
Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic linkage studies have mapped a locus (AD3) associated with susceptibility to a very aggressive form of Alzheimer's disease to chromosome 14q24.3. We have defined a minimal cosegregating...
Yan Cai et al.
The European journal of neuroscience, 32(7), 1223-1238 (2010-08-24)
Alzheimer's disease (AD) is the most common dementia-causing disorder in the elderly; it may be related to multiple risk factors, and is characterized pathologically by cerebral hypometabolism, paravascular β-amyloid peptide (Aβ) plaques, neuritic dystrophy, and intra-neuronal aggregation of phosphorylated tau....

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