This product may be stored in room temperature.
P5556
Poloxamer 188 solution
10%, sterile-filtered, BioReagent, suitable for insect cell culture
Synonym(s):
Nonionic copolymer surfactant
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12161902
PubChem Substance ID:
NACRES:
NA.75
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description
non-ionic
sterility
sterile-filtered
product line
BioReagent
mol wt
average mol wt 8350
concentration
10%
technique(s)
cell culture | insect: suitable
impurities
endotoxin, tested
transition temp
cloud point ≥100
HLB
29
SMILES string
O2C(C2)C.O1CC1
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
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This Item | 16758 | P2164009 | 1546150 |
|---|---|---|---|
| technique(s) cell culture | insect: suitable | technique(s) - | technique(s) - | technique(s) - |
| product line BioReagent | product line - | product line - | product line - |
| description non-ionic | description - | description - | description - |
| mol wt average mol wt 8350 | mol wt - | mol wt - | mol wt - |
| HLB 29 | HLB - | HLB - | HLB - |
| impurities endotoxin, tested | impurities ≤1.0% water | impurities - | impurities - |
General description
Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer. It comprises a central chain of hydrophobic polyoxypropylene flanked at ends by hydrophilic polyoxyethylene.[1]
Application
A nonionic copolymer surfactant
Biochem/physiol Actions
Poloxamer 188 (P188) elicits hemorheological, antithrombotic, anti-inflammatory, and cytoprotective activities. It restores and stabilizes membrane barrier function. P188 also inhibits lipid peroxidation, reduces surface tension and hydrophobic-based cellular adherence.[1][2] P-188 exhibits low toxicity and may be used in oral drug delivery.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Dina Mourad Saleh et al.
Particle and fibre toxicology, 17(1), 48-48 (2020-10-16)
Multi-walled carbon nanotubes can be divided into two general subtypes: tangled and straight. MWCNT-N (60 nm in diameter) and MWCNT-7 (80-90 nm in diameter) are straight-type MWCNTs, and similarly to asbestos, both are carcinogenic to the lung and pleura when administered to
Martin Emanuele et al.
Drugs in R&D, 14(2), 73-83 (2014-04-12)
Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer with hemorheologic, antithrombotic, anti-inflammatory, and cytoprotective properties. It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb ischemia, shock, acute stroke, heart failure, and sickle cell crisis.
Mimi R Borrelli et al.
Aesthetic surgery journal, 40(4), 369-379 (2019-04-12)
Breast capsular contracture is a major problem following implant-based breast reconstruction, particularly in the setting of radiation therapy. Recent work has identified a fibrogenic fibroblast subpopulation characterized by CD26 surface marker expression. This work aimed to investigate the role of
Deshka S Foster et al.
Nature communications, 11(1), 4061-4061 (2020-08-15)
Adhesions are fibrotic scars that form between abdominal organs following surgery or infection, and may cause bowel obstruction, chronic pain, or infertility. Our understanding of adhesion biology is limited, which explains the paucity of anti-adhesion treatments. Here we present a
Daniel Helman et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 85(2), 162-168 (2013-06-15)
We developed a membrane bound reporter and selection molecule for sorting by fluorescence activated cell sorting (FACS) of cells producing a protein of interest. This molecule is composed of a transmembrane (TM) domain, fused on its extracellular end to a
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what is the storage temperature for this product
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What is this compound dissolved in ? I can not see any information about that.
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This product is a 10% solution of Poloxamer 188 in water.
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How does the pH of the Poloxamer 188 solution fluctuate throughout a 24-month period?
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The pH of a solution containing Poloxamer 188 may change over time due to factors such as hydrolysis or oxidation. The pH stability of Poloxamer 188 solutions has not been conducted. However, end users are encouraged to periodically monitor the solutions to ensure their stability and efficacy.
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