Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

P5679

Sigma-Aldrich

3-Propylxanthine

≥99%, solid

Synonym(s):

Enprofylline

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C8H10N4O2
CAS Number:
41078-02-8
Molecular Weight:
194.19
Beilstein/REAXYS Number:
1116213
EC Number:
255-201-8
MDL number:
MFCD00043205
UNSPSC Code:
12352200
PubChem Substance ID:
24277687

assay

≥99%

form

solid

color

white

solubility

DMSO: soluble
H2O: slightly soluble (Solutions should be stored at 4°C.)
alcohol: soluble (Solutions should be stored at 4°C.)

SMILES string

CCCN1C(=O)NC(=O)c2[nH]cnc12

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Weak competitive antagonist at both A1 and A2 adenosine receptors.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
107H1438
092H2534
078H1660
024K4701
019H0822

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

I Feoktistov et al.
Biochemical pharmacology, 62(9), 1163-1173 (2001-11-14)
The antiasthmatic drug enprofylline was the first known selective, though not potent, A(2B) antagonist. On the basis of structure-activity relationships (SARs) of xanthine derivatives, we designed a novel selective adenosine A(2B) receptor antagonist, 3-isobutyl-8-pyrrolidinoxanthine (IPDX), with potency greater than that
Adenosine and adenosine antagonism in asthma.
C Persson
Thorax, 53(5), 437-438 (1998-08-26)
Jelena Mojsilovic-Petrovic et al.
Neuro-degenerative diseases, 2(3-4), 160-165 (2006-08-16)
The death of motor neurons in amyotrophic lateral sclerosis (ALS) is believed to result, in part, from unrestrained activation of glutamate receptors (excitotoxicity). In some in vitro models, excitotoxic death only occurs if motor neurons develop in the presence of
P Nieri et al.
Journal of autonomic pharmacology, 16(2), 55-62 (1996-04-01)
1. The acute (6h) exposure of guinea-pigs to white noise (110 dB) as a stress stimulus, reduced bronchial reactivity to acetylcholine (Ach) (3-1000 micrograms kg-1 i.v.) in anaesthetized animals. 2. The hyporesponsiveness to Ach in stressed animals was not confirmed
G Danialou et al.
British journal of pharmacology, 124(7), 1355-1362 (1998-09-02)
1. We investigated by intravital microscopy in rats, the in vivo direct effects of theophylline on the diameters of second and third order diaphragm arterioles. 2. Theophylline (1-100 microM) dilated second and third order diaphragm arterioles significantly, and with an
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service