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P5687

Sigma-Aldrich

Monoclonal Anti-Prostatic Acid Phosphatase, Human antibody produced in mouse

clone PAP-12, ascites fluid

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MDL number:
NACRES:
NA.46

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

PAP-12, monoclonal

contains

15 mM sodium azide

species reactivity

human

technique(s)

indirect ELISA: 1:800 using purified preparation of human prostatic acid phosphatase

isotype

IgG1

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ACPP(55)

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This Item
WH0000055M1P7607A2951
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

clone

PAP-12, monoclonal

clone

2D11, monoclonal

clone

PPI-377, monoclonal

clone

8B6, monoclonal

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

antibody form

ascites fluid

antibody form

purified immunoglobulin

antibody form

ascites fluid

antibody form

ascites fluid

Gene Information

human ... ACPP(55)

Gene Information

human ... ACPP(55)

Gene Information

human ... PPP1CA(5499)
mouse ... Ppp1ca(19045)
rat ... Ppp1ca(24668)

Gene Information

human ... ALPP(250)

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General description

The antibodies localize the 48 kDa subunit of prostatic acid phosphatase in immunoblotting, using reducing and denaturing conditions, without cross-reactivity to prostate specific antigen or other human serum or tissue proteins.

Immunogen

human prostatic acid phosphatase

Biochem/physiol Actions

Prostatic acid phosphatase (PAP) is a non-specific phosphomonoesterase synthesized in prostate epithelial cells. The major function of PAP is the regulation of prostate cell growth. The levels of PAP serve as marker for prostate cancer progression. PAP has been reported to exhibit antinociceptive effect in neuropathic and inflammatory pain that is characteristic of cancer-induced bone pain.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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Hoon Young Kong et al.
Biomolecules & therapeutics, 21(1), 10-20 (2013-09-07)
Prostate cancer is one of the most prevalent non-skin related cancers. It is the second leading cause of cancer deaths among males in most Western countries. If prostate cancer is diagnosed in its early stages, there is a higher probability
Lei Chen et al.
Pain physician, 16(6), 533-546 (2013-11-29)
Cancer-induced bone pain (CIBP) is a severe chronic pain that is less than adequately controlled by conventional analgesics. Prostatic acid phosphatase (PAP) has been considered as a diagnostic marker for prostate cancer and its transmembrane isoform has been reported to
Paulo R Bueno et al.
Nanoscale, 9(40), 15362-15370 (2017-10-04)
The application of nanoscale capacitance as a transduction of molecular recognition relevant to molecular diagnostics is demonstrated. The energy-related signal relates directly to the electron occupation of quantized states present in readily fabricated molecular junctions such as those presented by

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