The long-term stability of a stock solution stored at -20ºC has not been evaluated. It is recommended to prepare stock solutions in degassed water and store them in working aliquots in order to extend the stability. Solutions stored refrigerated are stable for 30 days. Frozen aliquots would be expected to be stable for at least as long as the refrigerated solution.
P5780
Putrescine dihydrochloride
powder, BioReagent, suitable for cell culture
Synonym(s):
1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tetramethylenediamine dihydrochloride
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About This Item
Linear Formula:
NH2(CH2)4NH2 · 2HCl
CAS Number:
Molecular Weight:
161.07
Beilstein/REAXYS Number:
3906680
EC Number:
MDL number:
UNSPSC Code:
12352207
PubChem Substance ID:
NACRES:
NA.75
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biological source
microbial
synthetic
product line
BioReagent
assay
≥97% (TLC)
form
powder
technique(s)
cell culture | mammalian: suitable
mp
280 °C (dec.) (lit.)
solubility
H2O: 100 mg/mL
SMILES string
Cl[H].Cl[H].NCCCCN
InChI
1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H
InChI key
XXWCODXIQWIHQN-UHFFFAOYSA-N
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This Item | P7505 | P6024 | 51799 |
|---|---|---|---|
| assay ≥97% (TLC) | assay ≥98% (TLC) | assay ≥97% (HPLC) | assay ≥98.5% (GC) |
| form powder | form powder | form lyophilized powder | form - |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) cell culture | mammalian: suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable |
| Quality Level 200 | Quality Level 400 | Quality Level 200 | Quality Level 100 |
| solubility H2O: 100 mg/mL | solubility H2O: soluble 100 mg/mL, clear, colorless | solubility cell culture medium: 0.16 mg/mL | solubility - |
| biological source microbial | biological source - | biological source synthetic (organic) | biological source - |
General description
Putrescine is an end product of fatty acid metabolism in dead tissues. It is a volatile diamine with pungent odour.[1] It is synthesized by the decarboxylation of ornithine in the presence of enzyme, ornithine decarboxylase.[2] Molecular docking studies reveal the binding of putrescine to human receptors called the trace amine-associated receptors (TAAR6 and TAAR8), present in olfactory epithelium.[3]
Application
Biochem/physiol Actions
Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.
Binds to the polyamine modulatory site of the NMDA receptor; potentiates NMDA-induced currents.
Putrescine is regarded as a marker of stress in plants. External supplementation of putrescine helps wheat plants to overcome drought stress.[6] It is crucial for cell proliferation in animals and modulates abscisic acid (ABA) levels during cold stress in Arabidopsis plants.[7] It serves as an attractant for predators.[4]
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk_germany
WGK 1
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors
Saunders LR and Verdin E
Molecular Cancer Therapeutics, 5(11), 2777-2785 (2006)
Polyamines and abiotic stress in plants: a complex relationship1
Minocha R, et al.
Frontiers in Plant Science, 5, 175-175 (2014)
A new assay for nerve fiber repulsion
Fassold A and Strau RH
Annals of the New York Academy of Sciences, 1193(1), 43-47 (2010)
The smell of death: evidence that putrescine elicits threat management mechanisms
Wisman A and Shrira I
Frontiers in Psychology, 6, 1274-1274 (2015)
Identifying human diamine sensors for death related putrescine and cadaverine molecules
Izquierdo C, et al.
PLoS Computational Biology, 14(1), e1005945-e1005945 (2018)
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