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MilliporeSigma

P6001

Sigma-Aldrich

p-Phenylenediamine

98% (GC)

Synonym(s):

1,4-Benzenediamine, 1,4-Diaminobenzene, 1,4-Phenylenediamine

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About This Item

Linear Formula:
C6H4(NH2)2
CAS Number:
Molecular Weight:
108.14
Beilstein/REAXYS Number:
742029
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.83

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vapor density

3.7 (vs air)

vapor pressure

1.08 mmHg ( 100 °C)

description

anti-fade reagent

assay

98% (GC)

bp

267 °C (lit.)

mp

138-143 °C (lit.)

SMILES string

Nc1ccc(N)cc1

InChI

1S/C6H8N2/c7-5-1-2-6(8)4-3-5/h1-4H,7-8H2

InChI key

CBCKQZAAMUWICA-UHFFFAOYSA-N

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1 of 4

This Item
78429695106P23954
assay

98% (GC)

assay

≥99.0% (GC/NT)

assay

≥99%

assay

99%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

bp

267 °C (lit.)

bp

267 °C (lit.)

bp

267 °C (lit.)

bp

282-284 °C

mp

138-143 °C (lit.)

mp

138-143 °C (lit.)

mp

138-143 °C (lit.)

mp

64-66 °C

vapor density

3.7 (vs air)

vapor density

3.7 (vs air)

vapor density

3.7 (vs air)

vapor density

3.7 (vs air)

vapor pressure

1.08 mmHg ( 100 °C)

vapor pressure

1.08 mmHg ( 100 °C)

vapor pressure

1.08 mmHg ( 100 °C)

vapor pressure

0.62 mmHg ( 100 °C)

Application

p-Phenylenediamine has been used:
  • to evaluate its sensitization potential in vitro in langerhans-like dendritic cells and autologous T cells[1]
  • to treat the dorsal sides of the ears of mice, to study its systemic immunological effects[2]
  • in glycerol to coverslip coronal sections in the attempt to count Aβ plaques[3]

Anti-fade reagent is added to the mounting medium in fluorescence microscopy to retard photobleaching of fluorescein and other fluorescent dyes.

Biochem/physiol Actions

p-Phenylenediamine causes allergic reactions with skin.[4] It is widely used in hair dyes. It eventually forms Bandrowski′s base, which is found to be the primary cause for allergy.[5] p-Phenylenediamine exposure results in dermatitis, urticaria and anaphylaxis.[6] It acts as an electron donor and is known to reduce cytochrome c.

Caution

Darkens in storage.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 1 Oral

target_organs

Kidney,Heart,Musculo-skeletal system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Questions

1–5 of 5 Questions  
  1. May I ask if I can use P- phenylenediamine for oxidase test 

    1 answer
    1. We have no information on using this product for oxidase test. Product No. T3134, N,N,N′,N′-Tetramethyl-p-phenylenediamine dihydrochloride is commonly used to perform the oxidase test for the colorimetric identification of pathogenic and non-pathogenic bacteria.

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  2. What is the working concentration for p-Phenylediamine, Product P6001, when used as an antifade agent?

    1 answer
    1. J. Immunological Methods, 43, 349 (1981) describes a solution that will reduce the fading of fluorescent materials. The recipe for this solution is: "Add 10 mL of phosphate-buffered saline (0.01 M PO4, pH 7.4 in 0.15 M NaCl) containing 100 mg of p-phenylenediamine to 90 ml of glycerol. The final pH should be adjusted to approximately 8.0 with 0.5 M carbonate-bicarbonate buffer (pH 9.0)".

      Helpful?

  3. What is the solubility of p-Phenylediamine, Product P6001?

    1 answer
    1. This product is soluble in ethanol at a concentration of 50 mg/mL, with heating. A clear red to brown solution is observed.

      Helpful?

  4. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  5. For what applications is p-Phenylediamine, Product P6001, used?

    1 answer
    1. This is an antifade reagent that is used as a fluorescent stabilizer. Do not confuse the p-phenylenediamine with o-phenylenediamine, which is used as a peroxidase substrate in ELISA procedures.

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