MilliporeSigma
All Photos(6)

P6004

Sigma-Aldrich

Prednisolone

≥99%

Synonym(s):
11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione, 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 1-Dehydrohydrocortisone, 1-Dehydrocortisol
Empirical Formula (Hill Notation):
C21H28O5
CAS Number:
Molecular Weight:
360.44
Beilstein:
1354103
EC Number:
MDL number:
PubChem Substance ID:

biological source

synthetic (organic)

sterility

non-sterile

assay

≥99%

form

powder

mp

240 °C (dec.) (lit.)

solubility

chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow

originator

Johnson & Johnson

shipped in

ambient

storage temp.

room temp

SMILES string

O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1

InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

OIGNJSKKLXVSLS-VWUMJDOOSA-N

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General description

Prednisolone prevents protease activity in vitro. It stimulates myogenesis and inhibits apoptosis. Prednisolone is used to treat Duchenne muscular dystrophy (DMD), gout arthritis and chronic obstructive pulmonary disease (COPD) exacerbations.

Application

Prednisolone has been used for the Δ1-dehydrogenation of hydrocortisone by gel entrapped arthrobacter simplex cells.

Packaging

100 mg in poly bottle
1, 5, 10, 25 g in poly bottle

Biochem/physiol Actions

Prednisolone is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Analysis Note

Actual content given on label

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Use of oral prednisolone or naproxen for the treatment of gout arthritis: a double-blind, randomised equivalence trial
Janssens HJEM, et al.
Lancet, 371(9627), 1854-1860 (2008)
Oral or IV Prednisolone in the Treatment of COPD Exacerbations
de Jong YP, et al.
Chest, 132(6), 1741-1747 (2007)
Prednisolone decreases cellular adhesion molecules required for inflammatory cell infiltration in dystrophin-deficient skeletal muscle
Wehling-Henricks M, et al.
Neuromuscular Disorders, 14(8-9), 483-490 (2004)
Shin Ebihara et al.
Arthritis research & therapy, 18(1), 139-139 (2016-06-16)
Dimethyl fumarate (DMF), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator, has been proven effective for the systemic treatment of multiple sclerosis. The aim of this study is to evaluate the anti-inflammatory effects of Nrf2 activators on human renal
Kang Ho Kim et al.
Molecular endocrinology (Baltimore, Md.), 30(8), 905-916 (2016-06-30)
Liver fibrosis is a reversible wound-healing process that is protective in the short term, but prolonged fibrotic responses lead to excessive accumulation of extracellular matrix components that suppresses hepatocyte regeneration, resulting in permanent liver damage. Upon liver damage, nonparenchymal cells

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