P6273

2-Propylpentanoic acid

• Synonym(s): Valproic acid
• Linear Formula: (CH₃CH₂CH₂)₂CHCO₂H
• CAS Number: 99-66-1
• Molecular Weight: 144.21
• EC Number: 202-777-3
• MDL number: MFCD00002672
• PubChem Substance ID: 24898751
• NACRES: NA.25

Properties

• Quality Level: 200
• refractive index: n20/D 1.425 (lit.)
• bp: 220 °C (lit.)
• solubility: H₂O: slightly soluble; alcohol: soluble
• density: 0.9 g/mL at 25 °C (lit.)
• SMILES string: CCCC(C(O)=O)CCC
• InChI: 1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
• InChI key: NIJJYAXOARWZEE-UHFFFAOYSA-N
• Gene Information: human ... ALDH5A1(7915) , CYP1A2(1544) ; mouse ... Hdac1(433759) ; rat ... Slc6a1(79212)

Description

Application

2-Propylpentanoic acid has been used as a supplement in mouse embryonic fibroblast - conditioned medium (MEF-CM) to feed the cells.

Biochem/physiol Actions

2-Propylpentanoic acid is a short-chain fatty acid and potentially inhibits histone deacetylase action. It is known to promote tumor cell toxicity and increase susceptibility to radiation. 2-Propylpentanoic acid elevates the levels of γ-aminobutyric acid in the brain. Reduced central nervous system action is observed in overdosage of 2-propylpentanoic acid. It enhance the inhibitory action of γ-aminobutyric acid (GABA) by blocking voltage-dependent sodium channel.

Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

Safety Information

• Pictograms: GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H302 - H315 - H319 - H360D
• Precautionary Statements: P201 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1A - Skin Irrit. 2
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): 231.8 °F
• Flash Point(C): 111 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves