P6280

Sigma-Aldrich

Pyridoxine hydrochloride

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

Synonym(s):
Adermine hydrochloride, Vitamin B6 hydrochloride, PN HCl, Pyridoxol hydrochloride
Empirical Formula (Hill Notation):
C8H11NO3 · HCl
CAS Number:
Molecular Weight:
205.64
Beilstein/REAXYS Number:
3632435
EC Number:
MDL number:
eCl@ss:
34058008
PubChem Substance ID:
NACRES:
NA.21

Quality Level

product line

BioReagent

assay

≥98% (HPLC)

form

powder

mol wt

Mw 205.64 g/mol

application(s)

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

color

white to off-white

mp

214-215 °C (lit.)

solubility

water: soluble 50 mg/mL, clear, colorless to faintly yellow

Featured Industry

Agriculture

SMILES string

Cl[H].Cc1ncc(CO)c(CO)c1O

InChI

1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H

InChI key

ZUFQODAHGAHPFQ-UHFFFAOYSA-N

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General description

Involved in a wide range of biochemical reactions that affect cell processes. Use as an alternative to pyridoxal which can degrade in media.

Packaging

10, 25, 100 g in poly bottle

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Carmela Vigorito et al.
International journal of molecular sciences, 20(9) (2019-05-11)
(1) The beneficial effects of hydrogen sulfide (H2S) on the cardiovascular and nervous system have recently been re-evaluated. It has been shown that lanthionine, a side product of H2S biosynthesis, previously used as a marker for H2S production, is dramatically...
Vijay P Singh et al.
The Journal of organic chemistry, 78(4), 1478-1487 (2013-01-16)
Vitamin B6 is involved in a variety of enzymatic transformations. Some recent findings also indicate an antioxidant role of the vitamin in biological systems. We set out to turn pyridoxine (1a) into a catalytic chain-breaking and hydroperoxide-decomposing antioxidant by replacing...
Manfred Eggersdorfer et al.
Angewandte Chemie (International ed. in English), 51(52), 12960-12990 (2012-12-05)
The discovery of vitamins as essential factors in the diet was a scientific breakthrough that changed the world. Diseases such as scurvy, rickets, beriberi, and pellagra were recognized to be curable with an adequate diet. These diseases had been prevalent...
Ilan Matok et al.
Journal of clinical pharmacology, 53(3), 334-338 (2013-02-28)
Although Diclectin (doxylamine/pyridoxine delayed-released combination) is widely used in Canada, its pharmacokinetics (PK) during pregnancy has never been described. The objective of this study was to compare the PK of doxylamine/pyridoxine delayed-released combination in pregnant versus nonpregnant women. The apparent...
Sonia Fargue et al.
Biochimica et biophysica acta, 1832(10), 1776-1783 (2013-04-20)
Primary hyperoxaluria type 1 (PH1) is a rare hereditary calcium oxalate kidney stone disease caused by a deficiency of the liver-specific pyridoxal-phosphate-dependent peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT). About one third of patients are responsive to pharmacological doses of pyridoxine (vitamin...
Articles
This page segues to comprehensive insights on how Vitamin B6, Pyridoxal and Pyridoxine affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies. The page introduces the in <i>vitro</i> chemistry and biochemistry of pyridoxal, pyridoxine.
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