Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
P7255
Puromycin dihydrochloride from Streptomyces alboniger
≥98% (HPLC), powder
Synonym(s):
3′-[α-Amino-p-methoxyhydrocinnamamido]-3′-deoxy-N,N-dimethyladenosine dihydrochloride
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$89.40
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$89.40
In StockDetails
Quality Level
assay
≥98% (HPLC)
form
powder
greener alternative product score
old score: 88
new score: 79
Find out more about DOZN™ Scoring
greener alternative product characteristics
Atom Economy
Design for Energy Efficiency
Use of Renewable Feedstocks
Design for Degradation
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
solubility
H2O: 50 mg/mL
antibiotic activity spectrum
Gram-positive bacteria
neoplastics
parasites
greener alternative category
mode of action
protein synthesis | interferes
Storage temp.
−20°C
SMILES string
Cl.Cl.COc1ccc(C[C@H](N)C(=O)N[C@H]2[C@@H](O)[C@@H](O[C@@H]2CO)n3cnc4c(ncnc34)N(C)C)cc1
InChI
1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16+,18+,22+;;/m0../s1
InChI key
MKSVFGKWZLUTTO-FZFAUISWSA-N
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This Item | P8833 | P9620 | SBR00017 |
|---|---|---|---|
| form powder | form powder | form solution | form liquid |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay >98% (HPLC) | assay ≥98% |
| Quality Level 300 | Quality Level 300 | Quality Level 300 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility H2O: 50 mg/mL | solubility - | solubility H2O: soluble 10 mg/mL | solubility - |
| greener alternative product score old score: 88 | greener alternative product score old score: 88 | greener alternative product score - | greener alternative product score - |
General description
Application
Biochem/physiol Actions
Mode of Resistance: Puromycin acetyltransferase is an effective resistance gene.
Antimicrobial Spectrum: This product is active against gram-positive microorganisms, less active against acid-fast bacilli and more weakly active against gram-negative microorganisms. Puromycin can prevent growth of bacteria, protozoa, algae and mammalian cells and acts quickly, killing 99% of cells within 2 days.
Features and Benefits
Caution
Preparation Note
Other Notes
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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How is shipping temperature determined? And how is it related to the product storage temperature?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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What are the approximate concentrations of Product P7288, Puromycin dihydrochloride, suitable for HEK293, A431 and Jurkat cells?
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HEK293: 2 μg/mL; A431: 1 μg/mL and Jurkat: 4 μg/mL.
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What are the approximate concentrations of Product P7255, Puromycin dihydrochloride, suitable for HeLa human uterus, B16 mouse melanoma and PC1.0 hamster adenocarcinoma cells?
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HeLa human uterus: 3 μg/mL; B16 mouse melanoma: 1-3 μg/mL; PC1.0 hamster adenocarcinoma: 10 μg/mL
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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