This product is not tested for suitability in HPLC. Unfortunately, no other Dihydrochloride form is tested for HPLC applications. However, the base form, available as a standard under product number 51799, has been tested for suitability in HPLC and GC. In addition, the purity of product D13208, 1,4-Diaminobutane (Putrescine), is determined by GC. Please see the links below to review these product options.
51799, Putrescine, analytical standard
https://www.sigmaaldrich.com/US/en/product/sial/51799
D13208, 1,4-Diaminobutane, 99%
https://www.sigmaaldrich.com/US/en/product/aldrich/d13208
P7505
Putrescine dihydrochloride
≥98% (TLC), powder
Synonym(s):
1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tetramethylenediamine dihydrochloride
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About This Item
Linear Formula:
NH2(CH2)4NH2 · 2HCl
CAS Number:
Molecular Weight:
161.07
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
206-375-9
MDL number:
Beilstein/REAXYS Number:
3906680
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Product Name
Putrescine dihydrochloride, ≥98% (TLC)
InChI key
XXWCODXIQWIHQN-UHFFFAOYSA-N
InChI
1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H
SMILES string
Cl[H].Cl[H].NCCCCN
assay
≥98% (TLC)
form
powder
mp
280 °C (dec.) (lit.)
solubility
H2O: soluble 100 mg/mL, clear, colorless
Quality Level
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Related Categories
1 of 4
This Item | P6024 | P5780 | SML0460 |
|---|---|---|---|
| assay ≥98% (TLC) | assay ≥97% (HPLC) | assay ≥97% (TLC) | assay ≥98% (HPLC) |
| form powder | form lyophilized powder | form powder | form powder |
| Quality Level 400 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| solubility H2O: soluble 100 mg/mL, clear, colorless | solubility cell culture medium: 0.16 mg/mL | solubility H2O: 100 mg/mL | solubility H2O: 5 mg/mL (clear solution) |
| mp 280 °C (dec.) (lit.) | mp 280 °C (dec.) (lit.) | mp 280 °C (dec.) (lit.) | mp - |
Application
Putrescine dihydrochloride has been used:
- as a bioactive amine standard in high-performance liquid chromatography (HPLC)[1]
- as a component of hormone mix supplemented to Dulbecco′s modified eagle medium (DMEM) to study its effects on neural stem cells[2]
- as a supplement in DMEM for culturing of endometrial cancer cells[3]
Biochem/physiol Actions
Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.
Binds to the polyamine modulatory site of the NMDA receptor; potentiates NMDA-induced currents.
Putrescine is an aliphatic amine and is positively charged.[4] It acts as a precursor of spermine and plays a role in polyamine biosynthesis.[4] Putrescine is found in several plants, animals, and bacteria. It plays a role in cell proliferation and cell growth in Escherichia coli.[5] Putrescine is a component of agrochemicals, surfactants, pharmaceuticals, polymers, and additives.[6]
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 1
flash_point_f
113.0 °F - closed cup
flash_point_c
45 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Mito Kanatsu-Shinohara et al.
Methods in enzymology, 477, 17-36 (2010-08-12)
Spermatogonial stem cells (SSCs) in the testes are a new target for germline modification. With the development of an in vitro culture system and spermatogonial transplantation technique, SSCs can now be manipulated and used as an alternative to embryonic stem
Ulises Gómez-Pinedo et al.
Frontiers in neurology, 8, 255-255 (2017-06-22)
Alexander disease (AxD) is a rare disease caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). The disease is characterized by presence of GFAP aggregates in the cytoplasm of astrocytes and loss of myelin. Determine the effect
Vegetables consumed in Brazilian cuisine as sources of bioactive amines
Dala-Paula B M, et al.
Food Bioscience, 40, 100856-100856 (2021)
Bangmin Liu et al.
Journal of animal science and biotechnology, 10, 69-69 (2019-09-14)
Polyamines are essential for cell growth and beneficial for intestinal maturation. To evaluate the effects of putrescine on alleviating intestinal atrophy and underlying molecular mechanisms, both in vivo feeding trial and in vitro cell culture were conducted. Weanling pigs were
Zhi-Gang Qian et al.
Biotechnology and bioengineering, 104(4), 651-662 (2009-08-29)
A four carbon linear chain diamine, putrescine (1,4-diaminobutane), is an important platform chemical having a wide range of applications in chemical industry. Biotechnological production of putrescine from renewable feedstock is a promising alternative to the chemical synthesis that originates from
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